# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4324468 | Binding | Displacement of RIP140 cofactor peptide from human His6-tagged RORgammat LBD (264 to 518 residues) by TR-FRET assay | Homo sapiens | 14 | ALA4321852 | single protein format | Scientific Literature | |
2. | ALA4324469 | Binding | Inhibition of human full-length eGFP-tagged RORgammat expressed in human HUT78 T-cells assessed as inhibition of PMA/CD3 monoclonal antibody stimulated IL-17 secretion after 48 hrs by ELISA | Homo sapiens | 11 | ALA4321852 | cell-based format | Scientific Literature | |
3. | ALA4324470 | Binding | Inhibition of RORgammat in rat CD4+ T-cells polarized with Th17 cytokine mix assessed as inhibition of IL-17 secretion | Rattus norvegicus | 8 | ALA4321852 | assay format | Scientific Literature | |
4. | ALA4324471 | Binding | Inverse agonist activity at RORgammat in rat whole blood assessed as reduction in Con A/IL-23-stimulated IL-17 secretion after 72 hrs by ELISA | Rattus norvegicus | 8 | ALA4321852 | tissue-based format | Scientific Literature | |
5. | ALA4324472 | Binding | Inverse agonist activity at RORgammat in human whole blood assessed as reduction in Con A/IL-23-stimulated IL-17 secretion after 72 hrs by ELISA | Homo sapiens | 8 | ALA4321852 | tissue-based format | Scientific Literature | |
6. | ALA4324477 | Physicochemical | Distribution coefficient of the compound, high-throughput logD using octanol-buffer at pH 7.4 by LC-MS/MS analysis shake flask method | 11 | ALA4321852 | small-molecule physicochemical format | Scientific Literature | ||
7. | ALA4324478 | ADME | Clearance in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 3 | ALA4321852 | organism-based format | Scientific Literature | |
8. | ALA4324479 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 3 | ALA4321852 | organism-based format | Scientific Literature | |
9. | ALA4324480 | ADME | Terminal half life in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 3 | ALA4321852 | organism-based format | Scientific Literature | |
10. | ALA4324481 | ADME | Dose normalized AUC in Sprague-Dawley rat at 1 mg/kg, iv | Rattus norvegicus | 3 | ALA4321852 | organism-based format | Scientific Literature | |
11. | ALA4324486 | ADME | Dose normalized AUC in DA rat at 5 mg/kg, po | Rattus norvegicus | 1 | ALA4321852 | organism-based format | Scientific Literature | |
12. | ALA4324487 | ADME | Oral bioavailability in DA rat at 3 mg/kg | Rattus norvegicus | 1 | ALA4321852 | organism-based format | Scientific Literature | |
13. | ALA4324488 | ADME | Dose normalized Cmax in DA rat at 5 mg/kg, po | Rattus norvegicus | 1 | ALA4321852 | organism-based format | Scientific Literature | |
14. | ALA4324489 | ADME | Tmax in DA rat at 5 mg/kg, po | Rattus norvegicus | 1 | ALA4321852 | organism-based format | Scientific Literature | |
15. | ALA4324490 | Binding | Inhibition of Gal4-tagged RORgammat LBD (unknown origin) by cell based luciferase reporter gene assay | Homo sapiens | 1 | ALA4321852 | cell-based format | Scientific Literature | |
16. | ALA4324491 | Binding | Inhibition of Gal4-tagged RORalpha LBD (unknown origin) by cell based luciferase reporter gene assay | Homo sapiens | 1 | ALA4321852 | cell-based format | Scientific Literature | |
17. | ALA4324492 | Binding | Inhibition of Gal4-tagged RORbeta LBD (unknown origin) by cell based luciferase reporter gene assay | Homo sapiens | 1 | ALA4321852 | cell-based format | Scientific Literature | |
18. | ALA4324493 | Binding | Inhibition of Gal4-tagged FXR LBD (unknown origin) by cell based luciferase reporter gene assay | Homo sapiens | 1 | ALA4321852 | cell-based format | Scientific Literature | |
19. | ALA4324494 | Binding | Inhibition of Gal4-tagged RXRalpha LBD (unknown origin) by cell based luciferase reporter gene assay | Homo sapiens | 1 | ALA4321852 | cell-based format | Scientific Literature | |
20. | ALA4324495 | Binding | Inhibition of Gal4-tagged ERalpha LBD (unknown origin) by cell based luciferase reporter gene assay | Homo sapiens | 1 | ALA4321852 | cell-based format | Scientific Literature |