# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4426782 | Binding | Inhibition of wild type phosphorylated MET (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide addition and measured after 5 mins by HTRF assay | Homo sapiens | 26 | ALA4425133 | single protein format | Scientific Literature | |
2. | ALA4426787 | Binding | Inhibition of phosphorylated MET Y1230H mutant (unknown origin) pre-incubated for 30 mins before biotinylated poly(glutamate-alanine-tyrosine) peptide addition and measured after 5 mins by HTRF assay | Homo sapiens | 23 | ALA4425133 | single protein format | Scientific Literature | |
3. | ALA4426789 | Physicochemical | Equilibrium solubility in phosphate buffer in absence of 10% Labrasol at pH 7.4 | 23 | ALA4425133 | small-molecule physicochemical format | Scientific Literature | ||
4. | ALA4426790 | Physicochemical | Equilibrium solubility in phosphate buffer in presence of 10% Labrasol at pH 7.4 | 23 | ALA4425133 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4426795 | ADME | Apparent permeability from apical to basolateral side in human Caco2/TC7 cells at 20 uM by liquid chromatography-tandem mass spectrometry | Homo sapiens | 13 | ALA4425133 | cell-based format | Scientific Literature | |
6. | ALA4426796 | ADME | Drug metabolism in human hepatic microsomes at 5 uM incubated for 20 mins in presence of NADPH by liquid chromatography-tandem mass spectrometry | Homo sapiens | 13 | ALA4425133 | microsome format | Scientific Literature | |
7. | ALA4426797 | ADME | Inhibition of human recombinant CYP3A4 co-expressed with human P450 reductase and human b5 reductase assessed as reduction in 7-Hydroxyquinoline production using 7-benzyloxyquinoline as substrate and NADPH incubated for 15 mins by fluorimetry | Homo sapiens | 13 | ALA4425133 | single protein format | Scientific Literature | |
8. | ALA4426799 | ADME | Mechanism based time dependent inhibition of human recombinant CYP3A4 co-expressed with human P450 reductase and human b5 reductase assessed as reduction in 7-Hydroxyquinoline production using 7-benzyloxyquinoline as substrate and NADPH measured every 3 mins for 15 mins by fluorimetry | Homo sapiens | 13 | ALA4425133 | single protein format | Scientific Literature |