| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4408554 | B | Inhibition of IDO1 in human HeLa cells using L-tryptophan as substrate incubated for 48 hrs | Homo sapiens | 34 | ALA4406833 | cell-based format | Scientific Literature | |
| 2. | ALA4408555 | B | Inhibition of recombinant N-terminal His-tagged human IDO1 expressed in Escherichia coli assessed as reduction in N-formylkynurenine formation using L-tryptophan as substrate | Homo sapiens | 14 | ALA4406833 | assay format | Scientific Literature | |
| 3. | ALA4408557 | B | Inhibition of N-terminal His-tagged human IDO2 expressed in Escherichia coli expression system | Homo sapiens | 4 | ALA4406833 | assay format | Scientific Literature | |
| 4. | ALA4408558 | B | Inhibition of N-terminal His-tagged human TDO expressed in Escherichia coli expression system | Homo sapiens | 4 | ALA4406833 | assay format | Scientific Literature | |
| 5. | ALA4408559 | A | Apparent permeability across apical to basolateral side in human Caco2 cells upto 90 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4406833 | cell-based format | Scientific Literature | |
| 6. | ALA4408560 | A | Efflux ratio of apparent permeability from basolateral side to apical side over apical side to basolateral side in human Caco2 cells upto 90 mins by LC-MS/MS analysis | Homo sapiens | 4 | ALA4406833 | cell-based format | Scientific Literature | |
| 7. | ALA4408561 | P | Aqueous solubility of compound at 1 mg after 30 hrs by HPLC analysis | 4 | ALA4406833 | small-molecule physicochemical format | Scientific Literature | ||
| 8. | ALA4408562 | A | Clearance in rat at 2.5 mg/kg, iv or 10 mg/kg, po after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4406833 | organism-based format | Scientific Literature | |
| 9. | ALA4408563 | A | Volume of distribution in rat at 10 mg/kg, po after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4406833 | organism-based format | Scientific Literature | |
| 10. | ALA4408564 | A | Half life in rat at 2.5 mg/kg, iv after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4406833 | organism-based format | Scientific Literature | |
| 11. | ALA4408565 | A | AUC in rat at 2.5 mg/kg, iv after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4406833 | organism-based format | Scientific Literature | |
| 12. | ALA4408566 | A | Oral bioavailability in rat at 10 mg/kg after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4406833 | organism-based format | Scientific Literature | |
| 13. | ALA4408567 | A | Half life in rat at 10 mg/kg, po after 24 hrs by LC-MS/MS analysis | Rattus norvegicus | 1 | ALA4406833 | organism-based format | Scientific Literature | |
| 14. | ALA4408568 | T | Toxicity in C57BL6 mouse allografted with Lewis cells assessed as increase in body weight at 30 to 60 mg/kg, ig measured every 3 days for 30 days | Mus musculus | 1 | ALA4406833 | organism-based format | Scientific Literature | |
| 15. | ALA4408570 | F | Antitumour activity against LLC cells allografted in C57BL6 mouse assessed as increase in survival at 15 to 60 mg/kg, ig after 30 days | Mus musculus | 1 | ALA4406833 | organism-based format | Scientific Literature | |
| 16. | ALA4408572 | F | Antimetastatic activity against LLC cells allografted in ig dosed C57BL6 mouse assessed as reduction in metastatic lung nodules after 30 days by H and E staining based analysis | Mus musculus | 1 | ALA4406833 | organism-based format | Scientific Literature | |
| 17. | ALA4408573 | F | Antimetastatic activity against LLC cells allografted in C57BL6 mouse assessed as reduction in metastatic area in lungs at 15 to 60 mg/kg, ig after 30 days by H and E staining based analysis | Mus musculus | 1 | ALA4406833 | organism-based format | Scientific Literature | |
| 18. | ALA4408574 | F | Antimetastatic activity against LLC cells allografted in C57BL6 mouse assessed as number of metastatic nodules in lung at 60 mg/kg, ig after 30 days by H and E staining based analysis | Mus musculus | 2 | ALA4406833 | organism-based format | Scientific Literature | |
| 19. | ALA4408575 | F | Antimetastatic activity against LLC cells allografted in C57BL6 mouse assessed as inhibition of metastatic nodules in lung at 60 mg/kg, ig after 30 days by H and E staining based analysis relative to control | Mus musculus | 2 | ALA4406833 | organism-based format | Scientific Literature | |
| 20. | ALA4408576 | A | Half life in human serum at 0.5 mM after 0.5 to 24 hrs by HPLC analysis | Homo sapiens | 1 | ALA4406833 | cell-free format | Scientific Literature |
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