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# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4390139 B Inhibition of human endothelial lipase derived from human HT1080 cell conditioned media using PED-A1 as substrate incubated for 20 mins and measured every 20 secs for 10 mins by FRET assay Homo sapiens 11 single protein format Scientific Literature 2. ALA4390140 B Inhibition of human hepatic lipase expressed in African green monkey COS7 cells using PED-A1 as substrate incubated for 20 mins and measured every 20 secs for 10 mins by FRET assay Homo sapiens 11 cell-based format Scientific Literature 3. ALA4390141 B Inhibition of mouse endothelial lipase expressed in HEK293F cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of mouse plasma by LC/MS analysis Mus musculus 8 cell-based format Scientific Literature 4. ALA4390142 A Cmax in Balb/c mouse at 10 mg/kg, po Mus musculus 5 organism-based format Scientific Literature 5. ALA4390143 A Plasma concentration in Balb/c mouse at 10 mg/kg, po measured after 7 hrs Mus musculus 5 organism-based format Scientific Literature 6. ALA4390144 A Plasma concentration in Balb/c mouse at 10 mg/kg, po measured after 24 hrs Mus musculus 4 organism-based format Scientific Literature 7. ALA4390145 A Tmax in Balb/c mouse at 10 mg/kg, po Mus musculus 4 organism-based format Scientific Literature 8. ALA4390146 A Total AUC in Balb/c mouse at 10 mg/kg, po measured after 24 hrs Mus musculus 5 organism-based format Scientific Literature 9. ALA4390147 A Metabolic stability in Balb/c mouse liver microsomes assessed as parent compound remaining at 0.5 uM measured after 10 mins Mus musculus 5 microsome format Scientific Literature 10. ALA4390148 A Permeability of compound at pH 5.5 by PAMPA 6 assay format Scientific Literature 11. ALA4390150 B Selectivity index, ratio of IC50 for inhibition of human hepatic lipase expressed in African green monkey COS7 cells to IC50 for inhibition of human endothelial lipase derived from human HT1080 cell conditioned media Homo sapiens 4 cell-based format Scientific Literature 12. ALA4390151 B Inhibition of human endothelial lipase using D31-POPC-HDL as substrate incubated for 2 hrs in presence of human serum by LC/MS analysis Homo sapiens 4 single protein format Scientific Literature 13. ALA4390152 B Inhibition of endothelial lipase in hepatic lipase knock-out mouse plasma using D31-POPC-HDL as substrate incubated for 2 hrs by LC/MS analysis Mus musculus 1 cell-free format Scientific Literature 14. ALA4390153 B Inhibition of hepatic lipase in endothelial lipase knock-out mouse plasma using D31-POPC-HDL as substrate incubated for 2 hrs by LC/MS analysis Mus musculus 1 cell-free format Scientific Literature 15. ALA4390154 A Cmax in Balb/c mouse at 20 mg/kg, po Mus musculus 1 organism-based format Scientific Literature 16. ALA4390155 A Plasma concentration in Balb/c mouse at 20 mg/kg, po measured after 7 hrs Mus musculus 1 organism-based format Scientific Literature 17. ALA4390156 A Plasma concentration in Balb/c mouse at 20 mg/kg, po measured after 24 hrs Mus musculus 1 organism-based format Scientific Literature 18. ALA4390157 A Tmax in Balb/c mouse at 20 mg/kg, po Mus musculus 1 organism-based format Scientific Literature 19. ALA4390158 A Half life in Balb/c mouse at 20 mg/kg, po Mus musculus 1 organism-based format Scientific Literature 20. ALA4390159 A Total AUC in Balb/c mouse at 20 mg/kg, po measured after 24 hrs Mus musculus 1 organism-based format Scientific Literature