# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4376398 | Functional | Induction of apoptosis in human NCI-H1975 cells assessed as activation of caspase 3 at 0.1 to 3 uM measured after 48 hrs immunoblot analysis | Homo sapiens | 2 | ALA4373735 | cell-based format | Scientific Literature | |
2. | ALA4376405 | Functional | Antiproliferative activity against human A549 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay | Homo sapiens | 13 | ALA4373735 | cell-based format | Scientific Literature | |
3. | ALA4376406 | Functional | Antiproliferative activity against human HCT116 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay | Homo sapiens | 13 | ALA4373735 | cell-based format | Scientific Literature | |
4. | ALA4376407 | Functional | Antiproliferative activity against human NCI-H1975 cells assessed as cell growth inhibition after 48 hrs by sulforhodamine B assay | Homo sapiens | 13 | ALA4373735 | cell-based format | Scientific Literature | |
5. | ALA4376408 | Binding | Inhibition of HDAC in human HeLa nuclear extract using Boc-Lys(acetyl)-AMC as substrate measured after 30 mins by fluorescence assay | Homo sapiens | 13 | ALA4373735 | cell-based format | Scientific Literature | |
6. | ALA4376409 | Binding | Inhibition of FITC-geldanamycin binding to recombinant human full-length C-terminal His-tagged HSP90alpha expressed in Escherichia coli after 3 hrs by fluorescence polarization assay | Homo sapiens | 13 | ALA4373735 | assay format | Scientific Literature | |
7. | ALA4376410 | Binding | Inhibition of recombinant full length human FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in baculovirus infected insect cells using RHK-K(Ac)-AMC as substrate measured after 60 mins by fluorimetric assay | Homo sapiens | 2 | ALA4373735 | cell-based format | Scientific Literature | |
8. | ALA4376411 | Binding | Inhibition of recombinant human GST-tagged HDAC2 (1 to 488 residues) expressed in baculovirus infected sf21 cells using RHK-K(Ac)-AMC as substrate after 60 mins by fluorimetry assay | Homo sapiens | 2 | ALA4373735 | cell-based format | Scientific Literature | |
9. | ALA4376412 | Binding | Inhibition of human recombinant full length C-terminal His-tagged HDAC3 (1 to 428 residues) expressed in baculovirus infected insect cells using RHK-K(Ac)-AMC as substrate after 60 mins by fluorimetry analysis | Homo sapiens | 2 | ALA4373735 | cell-based format | Scientific Literature | |
10. | ALA4376413 | Binding | Inhibition of recombinant N-terminal GST-tagged and C-terminal His-tagged human HDAC4 expressed in baculovirus infected insect cells using RHK-K(Ac)-AMC as substrate after 60 mins by fluorimetry analysis | Homo sapiens | 2 | ALA4373735 | cell-based format | Scientific Literature | |
11. | ALA4376414 | Binding | Inhibition of recombinant human C-terminal His-fusion tagged HDAC5 (657 to 1123 residues) expressed in baculovirus infected insect cells using Boc-K(Ac)-AMC as substrate after 60 mins by fluorimetry analysis | Homo sapiens | 2 | ALA4373735 | cell-based format | Scientific Literature | |
12. | ALA4376415 | Binding | Inhibition of recombinant human N-terminal GST-tagged HDAC6 (1 to 1125 residues) expressed in baculovirus infected insect cells using RHK-K(Ac)-AMC as substrate after 90 mins by fluorimetry analysis | Homo sapiens | 2 | ALA4373735 | cell-based format | Scientific Literature | |
13. | ALA4376416 | Binding | Inhibition of recombinant human N-terminal GST-tagged HDAC7 (518 to 991 residues) expressed in baculovirus infected insect cells using Boc-K(Ac)-AMC as substrate after 90 mins by fluorimetry analysis | Homo sapiens | 2 | ALA4373735 | cell-based format | Scientific Literature | |
14. | ALA4376417 | Binding | Inhibition of recombinant C-terminal His-fusion tagged and N-terminal Streptavidin2-tagged human HDAC8 (1 to 377 residues) expressed in insect cells using RHK-K(Ac)-AMC as substrate after 60 mins by fluorescence assay | Homo sapiens | 2 | ALA4373735 | cell-based format | Scientific Literature | |
15. | ALA4376418 | Binding | Inhibition of human HDAC9 using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorescence assay | Homo sapiens | 2 | ALA4373735 | single protein format | Scientific Literature | |
16. | ALA4376419 | Binding | Inhibition of human HDAC10 using fluorescent-labelled p53 residues 379 to 382 (RHKKAc) peptide as substrate by fluorescence assay | Homo sapiens | 2 | ALA4373735 | single protein format | Scientific Literature | |
17. | ALA4376420 | Binding | Inhibition of human recombinant N-terminal Streptavidin2-tagged HDAC11 (1 to 347 residues) expressed in baculovirus infected insect cells using Boc-Lys(TFA)-AMC as substrate after 60 mins by fluorescence assay | Homo sapiens | 2 | ALA4373735 | cell-based format | Scientific Literature | |
18. | ALA4376421 | Binding | Inhibition of human recombinant N-terminal His-tagged SIRT1 (1 to 747 residues) expressed in Escherichia coli using Ac-RHK-K(Ac)-AMC as substrate after 30 mins in presence of NAD+ by fluorimetry analysis | Homo sapiens | 2 | ALA4373735 | assay format | Scientific Literature | |
19. | ALA4376422 | Binding | Inhibition of HSP90 in human H1975 cells assessed as induction of HSP70 expression by Western blot analysis | Homo sapiens | 2 | ALA4373735 | cell-based format | Scientific Literature | |
20. | ALA4376423 | Binding | Inhibition of HSP90 in human H1975 cells assessed as downregulation of EGFR protein level by Western blot analysis | Homo sapiens | 2 | ALA4373735 | cell-based format | Scientific Literature |