| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4339020 | ADME | MRT in Balb/C mouse at 5 mg/kg, iv | Mus musculus | 1 | ALA4334552 | organism-based format | Scientific Literature | |
| 2. | ALA4339021 | ADME | Half life in Balb/C mouse at 5 mg/kg, iv | Mus musculus | 1 | ALA4334552 | organism-based format | Scientific Literature | |
| 3. | ALA4339023 | Binding | Inhibition of PDE4 (unknown origin) by HTRF assay | Homo sapiens | 1 | ALA4334552 | protein format | Scientific Literature | |
| 4. | ALA4339024 | ADME | Cmax in Balb/C mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4334552 | organism-based format | Scientific Literature | |
| 5. | ALA4339025 | Binding | Inhibition of wild type His-tagged TGFBR2 kinase domain (unknown origin) incubated for 1 hr by HTRF analysis | Homo sapiens | 7 | ALA4334552 | single protein format | Scientific Literature | |
| 6. | ALA4339026 | ADME | Tmax in Balb/C mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4334552 | organism-based format | Scientific Literature | |
| 7. | ALA4339027 | ADME | Total AUC in Balb/C mouse at 5 mg/kg, iv | Mus musculus | 1 | ALA4334552 | organism-based format | Scientific Literature | |
| 8. | ALA4339028 | ADME | Total AUC in Balb/C mouse at 10 mg/kg, po | Mus musculus | 1 | ALA4334552 | organism-based format | Scientific Literature | |
| 9. | ALA4339029 | ADME | Metabolic stability of compound in rat liver microsomes assessed as compound remaining after 10 mins | Rattus norvegicus | 6 | ALA4334552 | microsome format | Scientific Literature | |
| 10. | ALA4339030 | ADME | Metabolic stability of compound in human liver microsomes assessed as compound remaining | Homo sapiens | 6 | ALA4334552 | microsome format | Scientific Literature | |
| 11. | ALA4339031 | Functional | Antitumour activity against mouse MC38 cells allografted in C57Bl/6 mouse assessed as reduction in tumour growth at 3.75 mg/kg, po dosed every 3 days on and 4 days off treatment regime and cotreated with anti-PD1 at 10 mg/kg, ip every 4 days for 3 doses by digital caliper analysis | Mus musculus | 1 | ALA4334552 | organism-based format | Scientific Literature | |
| 12. | ALA4339032 | ADME | Half life in dog liver microsomes in presence of NADPH | Canis lupus familiaris | 1 | ALA4334552 | microsome format | Scientific Literature | |
| 13. | ALA4339033 | ADME | Half life in human liver microsomes in presence of NADPH | Homo sapiens | 1 | ALA4334552 | microsome format | Scientific Literature | |
| 14. | ALA4339034 | Binding | Inhibition of TGFBR1 in TGFbeta-stimulated human NHLF cells assessed as reduction in SMAD2 nuclear translocation | Homo sapiens | 6 | ALA4334552 | assay format | Scientific Literature | |
| 15. | ALA4339035 | Binding | Inhibition of TGFbetaR1 in TGFbeta-stimulated mink Mv1Lu cells assessed as reduction in SMAD nuclear translocation preincubated for 1 hr followed by TGFbeta-stimulation for 15 mins by array scan based method | Neovison vison | 6 | ALA4334552 | assay format | Scientific Literature | |
| 16. | ALA4339036 | ADME | Protein binding in human serum assessed as unbound fraction | Homo sapiens | 1 | ALA4334552 | cell-free format | Scientific Literature | |
| 17. | ALA4339037 | Binding | Inhibition of His-tagged TGFBR1 kinase domain T204D mutant (unknown origin) incubated for 1 hr by HTRF analysis | Homo sapiens | 7 | ALA4334552 | single protein format | Scientific Literature | |
| 18. | ALA4339038 | ADME | Protein binding in dog serum assessed as unbound fraction | Canis lupus familiaris | 1 | ALA4334552 | cell-free format | Scientific Literature | |
| 19. | ALA4339039 | ADME | Protein binding in mouse serum assessed as unbound fraction | Mus musculus | 1 | ALA4334552 | cell-free format | Scientific Literature | |
| 20. | ALA4339040 | ADME | Protein binding in rat serum assessed as unbound fraction | Rattus norvegicus | 1 | ALA4334552 | cell-free format | Scientific Literature |
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