# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4314430 | F | Antiviral activity against human norovirus infected in human HG23 cells assessed as inhibition of viral replication at 10 uM after 3 days by qRT-PCR analysis relative to control | Norovirus | 37 | ALA4311988 | organism-based format | Scientific Literature | |
2. | ALA4314431 | A | Cytotoxicity against human HG23 cells assessed as cell viability at 10 uM after 3 days by tetrazolium dye based assay relative to control | Homo sapiens | 37 | ALA4311988 | cell-based format | Scientific Literature | |
3. | ALA4314432 | A | Cytotoxicity against human HG23 cells assessed as reduction in cell viability after 3 days by tetrazolium dye based assay | Homo sapiens | 5 | ALA4311988 | cell-based format | Scientific Literature | |
4. | ALA4314433 | F | Antiviral activity against human norovirus infected in human HG23 cells assessed as inhibition of viral replication after 3 days by qRT-PCR analysis | Norovirus | 5 | ALA4311988 | organism-based format | Scientific Literature | |
5. | ALA4314434 | T | Therapeutic index, ratio of CC50 for cytotoxicity against human HG23 cells harboring human norovirus replicons to EC50 for antiviral activity against norovirus infected in human HG23 cells | 5 | ALA4311988 | cell-based format | Scientific Literature | ||
6. | ALA4314435 | F | Antiviral activity against human norovirus infected in HG23 cells assessed as inhibition of neomycin phosphotransferase protein expression after 5 days by Western blot analysis | Norovirus | 1 | ALA4311988 | organism-based format | Scientific Literature | |
7. | ALA4314437 | B | Inhibition of norovirus GII.4 RNA-dependent RNA polymerase using poly(C)RNA as substrate incubated for 10 mins and measured after 15 mins by picogreen staining based assay | Norovirus GII.4 | 3 | ALA4311988 | assay format | Scientific Literature | |
8. | ALA4314438 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM preincubated for 5 mins followed by NADPH addition and measured after 30 mins by LC-MS/MS analysis relative to control | Homo sapiens | 4 | ALA4311988 | microsome format | Scientific Literature | |
9. | ALA4314439 | A | Metabolic stability in human liver microsomes assessed as compound remaining at 1 uM after 30 mins in absence of NADPH by LC-MS/MS analysis relative to control | Homo sapiens | 3 | ALA4311988 | microsome format | Scientific Literature | |
10. | ALA4314440 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining at 1 uM preincubated for 5 mins followed by NADPH addition and measured after 30 mins in presence of NADPH relative to control | Mus musculus | 3 | ALA4311988 | microsome format | Scientific Literature | |
11. | ALA4314441 | A | Metabolic stability in mouse liver microsomes assessed as compound remaining at 1 uM after 30 mins in absence of NADPH by LC-MS/MS analysis relative to control | Mus musculus | 3 | ALA4311988 | microsome format | Scientific Literature | |
12. | ALA4314442 | F | Antiviral activity against MNV-1 infected in mouse RAW264.7 cells at 0.05 to 10 uM after 48 hrs by crystal violet staining based assay | Murine norovirus 1 | 1 | ALA4311988 | cell-based format | Scientific Literature | |
13. | ALA4314443 | F | Antiviral activity against feline calicivirus- infected in cat CRFK cells at >5 uM after 48 hrs by crystal violet staining based assay | Feline calicivirus | 1 | ALA4311988 | organism-based format | Scientific Literature | |
14. | ALA4314444 | B | Activation of NRF2 pathway in human HG23 cells transfected with human norovirus at 10 uM after 72 hrs by dual-luciferase reporter gene assay | Homo sapiens | 1 | ALA4311988 | cell-based format | Scientific Literature | |
15. | ALA4314445 | B | Activation of HSF-1 in human HG23 cells transfected with human norovirus at 10 uM after 72 hrs by dual-luciferase reporter gene assay | Homo sapiens | 1 | ALA4311988 | cell-based format | Scientific Literature | |
16. | ALA4314446 | B | Activation of HSF-1 in human HG23 cells transfected with human norovirus after 72 hrs by dual-luciferase reporter gene assay | Homo sapiens | 2 | ALA4311988 | cell-based format | Scientific Literature |