# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4351503 | Binding | Displacement of [3H]Ro-15-1788 from human GABA alpha2/beta2/gamma2 receptor expressed in HEK cell membranes measured after 2 hrs by topcount method | Homo sapiens | 50 | ALA4350959 | cell-based format | Scientific Literature | |
2. | ALA4351505 | ADME | Positive allosteric modulation of human GABAA alpha1/beta3/gamma2 expressed in HEK293 cells assessed as increase in GABA-stimulated chloride current response at 100 times Ki measured after 15 secs by QPatch electrophysiology method relative to GABA | Homo sapiens | 50 | ALA4350959 | cell-based format | Scientific Literature | |
3. | ALA4351506 | Binding | Positive allosteric modulation of human GABAA alpha2/beta2/gamma2 expressed in HEK293 cells assessed as increase in GABA-stimulated chloride current response at 100 times Ki measured after 15 secs by QPatch electrophysiology method relative to GABA | Homo sapiens | 50 | ALA4350959 | cell-based format | Scientific Literature | |
4. | ALA4351508 | Physicochemical | Lipophilicity, log D of the compound | 34 | ALA4350959 | small-molecule physicochemical format | Scientific Literature | ||
5. | ALA4351509 | ADME | Intrinsic clearance in human liver microsomes | Homo sapiens | 46 | ALA4350959 | microsome format | Scientific Literature | |
6. | ALA4351510 | ADME | Efflux ratio of permeability across apical to basolateral side over basolateral to apical side in MDCK-MDR1 cells at 2 uM | Canis lupus familiaris | 46 | ALA4350959 | cell-based format | Scientific Literature |