# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4416105 | Binding | Inhibition of GST-tagged human EGFR kinase domain (696 to 1022 residues) using poly(Glu, Tyr) 4:1 substrate incubated for 60 mins by kinase-Glo plus luminescent kinase assay | Homo sapiens | 26 | ALA4414600 | single protein format | Scientific Literature | |
2. | ALA4416106 | Binding | Inhibition of GST-tagged human EGFR kinase domain I858R/T790M mutant (696 to 1022 residues) using EGFR L858R/T790M substrate peptide incubated for 120 mins by kinase-Glo plus luminescent kinase assay | Homo sapiens | 26 | ALA4414600 | single protein format | Scientific Literature | |
3. | ALA4416107 | Functional | Cytotoxicity in human HCC827 cells assessed as reduction in cell viability incubated for 96 hrs by MTS method | Homo sapiens | 26 | ALA4414600 | cell-based format | Scientific Literature | |
4. | ALA4416108 | Functional | Cytotoxicity in human NCI-H1975 cells assessed as reduction in cell viability incubated for 96 hrs by MTS method | Homo sapiens | 26 | ALA4414600 | cell-based format | Scientific Literature | |
5. | ALA4416109 | Binding | Inhibition of GST-tagged human EGFR A763_Y764insFHEA mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent kinase assay | Homo sapiens | 6 | ALA4414600 | single protein format | Scientific Literature | |
6. | ALA4416110 | Binding | Inhibition of GST-tagged human EGFR D770GY mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent kinase assay | Homo sapiens | 6 | ALA4414600 | assay format | Scientific Literature | |
7. | ALA4416111 | Binding | Inhibition of GST-tagged human EGFR D770_N771insNPG mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent kinase assay | Homo sapiens | 6 | ALA4414600 | single protein format | Scientific Literature | |
8. | ALA4416112 | Binding | Inhibition of GST-tagged human HER2 V777_G778insCG mutant mutant using poly(Glu, Tyr) 4:1 substrate incubated for 120 mins by kinase-Glo plus luminescent kinase assay | Homo sapiens | 6 | ALA4414600 | assay format | Scientific Literature | |
9. | ALA4416113 | Functional | Cytotoxicity in human A431 cells assessed as reduction in cell viability incubated for 96 hrs by MTS method | Homo sapiens | 6 | ALA4414600 | cell-based format | Scientific Literature |