# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4395370 | Binding | Inhibition of recombinant N-terminal His6-tagged Mycobacterium tuberculosis H37Rv IMPDH expressed in Escherichia coli BL21 (DE3) cells assessed as reduction of NAD+ to NADH using IMP and NAD+ as substrate treated 1 min after substrate incubation with enzyme by UV-visible spectrophotometry | Mycobacterium tuberculosis H37Rv | 49 | ALA4393693 | cell-based format | Scientific Literature | |
2. | ALA4395371 | Functional | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as reduction in bacterial cell growth incubated for 3 to 4 weeks by alamar blue fluorescence based broth microdilution assay | Mycobacterium tuberculosis | 49 | ALA4393693 | organism-based format | Scientific Literature | |
3. | ALA4395372 | Functional | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv SRMV2.6 harboring GuaB2 Tyr487Cys mutant assessed as reduction in bacterial cell growth incubated for 3 to 4 weeks by alamar blue fluorescence based broth microdilution assay | Mycobacterium tuberculosis | 49 | ALA4393693 | organism-based format | Scientific Literature | |
4. | ALA4395373 | Binding | Selective ratio of inhibition of GuaB2 Tyr487Cys mutant in Mycobacterium tuberculosis H37Rv SRMV2.6 to inhibition of wild type GuaB2 in Mycobacterium tuberculosis H37Rv | 49 | ALA4393693 | assay format | Scientific Literature |