# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4308355 | Binding | Inhibition of Trypanosoma cruzi cruzain using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate addition by fluorescence based analysis | Trypanosoma cruzi | 27 | ALA4304821 | single protein format | Scientific Literature | |
2. | ALA4308357 | Physicochemical | Lipophilicity, log Kw of compound by HPLC analysis | 19 | ALA4304821 | small-molecule physicochemical format | Scientific Literature | ||
3. | ALA4308358 | Functional | Antitrypanosomal activity against Trypanosoma cruzi Y strain amastigotes infected in human U2OS cells assessed as parasite growth inhibition after 72 hrs post infection by DRAQ5 staining based analysis | Trypanosoma cruzi | 27 | ALA4304821 | organism-based format | Scientific Literature | |
4. | ALA4308360 | Binding | Inhibition of Trypanosoma cruzi cruzain assessed as initial velocity using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate addition by fluorescence based analysis | Trypanosoma cruzi | 18 | ALA4304821 | single protein format | Scientific Literature | |
5. | ALA4308361 | Binding | Inhibition of Trypanosoma cruzi cruzain assessed as inhibitor constant using Z-Phe-Arg-7-amido-4-methylcoumarin as substrate preincubated for 2 mins followed by susbtrate addition by fluorescence based analysis | Trypanosoma cruzi | 18 | ALA4304821 | single protein format | Scientific Literature |