| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4410844 | A | MRT in rat | Rattus norvegicus | 8 | assay format | Scientific Literature | ||
| 2. | ALA4410845 | A | Clearance in human Hepatocyte | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 3. | ALA4410846 | B | Inhibition of recombinant His-tagged IDO1 (unknown origin) expressed in Escherichia coli preincubated for 30 mins followed by substrate tryptophan addition and measured after 60 mins by fluorescence based assay | Homo sapiens | 19 | assay format | Scientific Literature | ||
| 4. | ALA4410847 | B | Inhibition of IDO1 in human HeLa cells stimulated with IFNgamma using L-tryptophan as substrate incubated for 48 hrs by fluorescence based assay | Homo sapiens | 19 | cell-based format | Scientific Literature | ||
| 5. | ALA4410848 | B | Inhibition of IDO1 in human whole blood stimulated with IFNgamma/LPS using L-tryptophan/kynurenine as substrate incubated for 15 mins followed by IFNgamma/LPS stimulation and incubated for 18 hrs by LC/MS-MS analysis | Homo sapiens | 7 | tissue-based format | Scientific Literature | ||
| 6. | ALA4410849 | B | Inhibition of IDO1 in human whole blood stimulated with IFNgamma/LPS assessed as unbound potency using L-tryptophan/kynurenine as substrate incubated for 15 mins followed by IFNgamma/LPS stimulation and incubated for 18 hrs by LC/MS-MS analysis | Homo sapiens | 7 | tissue-based format | Scientific Literature | ||
| 7. | ALA4410850 | P | Lipophilicity, log D of compound at pH 7 by HPLC analysis | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 8. | ALA4410851 | A | Total clearance in rat | Rattus norvegicus | 8 | assay format | Scientific Literature | ||
| 9. | ALA4410852 | A | Intrinsic clearance in rat | Rattus norvegicus | 8 | assay format | Scientific Literature | ||
| 10. | ALA4410853 | A | Apparent permeability of compound | 1 | assay format | Scientific Literature | |||
| 11. | ALA4410854 | A | Half life in rat | Rattus norvegicus | 1 | assay format | Scientific Literature | ||
| 12. | ALA4410855 | A | Oral bioavailability in rat | Rattus norvegicus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4410856 | A | Clearance in dog | Canis lupus familiaris | 1 | assay format | Scientific Literature | ||
| 14. | ALA4410857 | A | Unbound clearance in dog | Canis lupus familiaris | 1 | assay format | Scientific Literature | ||
| 15. | ALA4410858 | A | Half life in dog | Canis lupus familiaris | 1 | assay format | Scientific Literature | ||
| 16. | ALA4410859 | A | Oral bioavailability in dog | Canis lupus familiaris | 1 | organism-based format | Scientific Literature | ||
| 17. | ALA4410860 | B | Inhibition of TDO in human SW480 cells incubated for 48 hrs using L-tryptophan as substrate by fluorescence based assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 18. | ALA4410861 | A | Inhibition of CYP450 (unknown origin) | Homo sapiens | 1 | protein format | Scientific Literature | ||
| 19. | ALA4410862 | B | Activation of PXR (unknown origin) | Homo sapiens | 1 | single protein format | Scientific Literature | ||
| 20. | ALA4410863 | T | Toxicity in rat assessed as adverse event | Rattus norvegicus | 1 | assay format | Scientific Literature |
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