# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4418132 | B | Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated anion exchange at 25 uM incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 22 | cell-based format | Patent Bioactivity Data | ||
2. | ALA4418133 | B | Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17SCN(-) exchange incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
3. | ALA4418134 | B | Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17F exchange incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
4. | ALA4418135 | B | Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated Cl(-)/r exchange incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
5. | ALA4418136 | B | Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17NO3(-) exchange incubated for 10 mins by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
6. | ALA4418137 | B | Reversible inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17SCN(-) exchange incubated for 10 mins measured after wash out by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
7. | ALA4418138 | B | Time dependent inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17SCN(-) exchange by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
8. | ALA4418139 | B | Inhibition of human pendrin expressed in FRT cells co-expressing EYFP-HIF assessed as reduction in pendrin-mediated C17HCO3(-) exchange by measuring reduction in cytoplasmic alkalinization exchange at 25 uM by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Homo sapiens | 2 | cell-based format | Patent Bioactivity Data | ||
9. | ALA4418158 | B | Inhibition of mouse pendrin expressed in FRT cells co-expressing YFP-HIF assessed as reduction in pendrin-mediated exchange of Cl(-) with SCN(-) by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Mus musculus | 1 | cell-based format | Patent Bioactivity Data | ||
10. | ALA4418159 | B | Inhibition of mouse pendrin expressed in FRT cells co-expressing YFP-HIF assessed as reduction in pendrin-mediated exchange of Cl(-) with I(-) by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Mus musculus | 1 | cell-based format | Patent Bioactivity Data | ||
11. | ALA4418160 | B | Inhibition of mouse pendrin expressed in FRT cells co-expressing YFP-HIF assessed as reduction in pendrin-mediated exchange of Cl(-) with NO3(-) by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Mus musculus | 1 | cell-based format | Patent Bioactivity Data | ||
12. | ALA4418161 | B | Inhibition of mouse pendrin expressed in FRT cells co-expressing YFP-HIF assessed as reduction in pendrin-mediated kinetics of CI7HCO3(-) exchange by pH-sensitive fluorescent probe BCECF-AM based fluorescence assay relative to control | Mus musculus | 1 | cell-based format | Patent Bioactivity Data | ||
13. | ALA4418162 | B | Inhibition of mouse Slc4a1 expressed in COS7 co-expressing EYFP-HIF assessed as effect on SCN(-) gradient at 25 uM by YFP-based fluorescence quenching assay | Mus musculus | 1 | assay format | Patent Bioactivity Data | ||
14. | ALA4418163 | B | Inhibition of myc-tagged mouse Slc26a3 expressed in COS7 co-expressing EYFP-HIF assessed as effect on SCN(-) gradient at 25 uM by YFP-based fluorescence quenching assay | Mus musculus | 1 | assay format | Patent Bioactivity Data | ||
15. | ALA4418164 | B | Inhibition of human NKCC1 expressed in COS7 co-expressing EYFP-HIF assessed as effect on I(-) gradient at 25 uM by YFP-based fluorescence quenching assay | Homo sapiens | 1 | assay format | Patent Bioactivity Data | ||
16. | ALA4418165 | A | Effect on renal function in CD1 mouse assessed as effect on urine pH at 50 mg/kg, ip | Mus musculus | 2 | organism-based format | Patent Bioactivity Data | ||
17. | ALA4418166 | A | Effect on renal function in CD1 mouse assessed as effect on blood gas values at 50 mg/kg, ip | Mus musculus | 2 | organism-based format | Patent Bioactivity Data | ||
18. | ALA4418167 | A | Effect on renal function in CD1 mouse assessed as effect on urinary salt excretion at 50 mg/kg, ip measured at 3 hrs | Mus musculus | 2 | organism-based format | Patent Bioactivity Data | ||
19. | ALA4418168 | A | Effect on renal function in C57B/6 mouse assessed as effect on urine pH at 50 mg/kg, ip | Mus musculus | 2 | organism-based format | Patent Bioactivity Data | ||
20. | ALA4418169 | A | Effect on renal function in C57B/6 mouse assessed as effect on blood gas values at 50 mg/kg, ip | Mus musculus | 2 | organism-based format | Patent Bioactivity Data |