# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4418839 | B | Inhibition of GST-tagged CUL4A/Rbxl ubiquitin ligase activity (unknown origin) assessed as reduction in reconstituted DDB1 ubiquitination at 15 uM in presence of ubiquitin, El, E2 and DDB1 incubated for 1 hr by Western blotting analysis relative to control | Homo sapiens | 31 | ALA4418496 | single protein format | Patent Bioactivity Data | |
2. | ALA4418841 | B | Inhibition of CUL4A in mouse MEF cells stably expressing FL FLAG-tagged DDB2 assessed as reduction in F-DDB2 degradation incubated for 2 hrs before irradiated with 10 J/m2 UV irradiation | Mus musculus | 21 | ALA4418496 | cell-based format | Patent Bioactivity Data | |
3. | ALA4418843 | B | Inhibition of CUL4A in mouse MEF cells stably expressing FL FLAG-tagged DDB2 assessed as reduction in F-DDB2 degradation incubated for 2 hrs before irradiated with 10 J/m2 UV irradiation relative to control | Mus musculus | 2 | ALA4418496 | cell-based format | Patent Bioactivity Data | |
4. | ALA4418844 | B | Inhibition of CUL1 in human U20S cells assessed as reduction in TNF-alpha-induced IkappaB-alpha degradation at 50 uM incubated for 2 hrs followed by TNFalpha stimulation for 15 mins by Western blotting analysis | Homo sapiens | 6 | ALA4418496 | cell-based format | Patent Bioactivity Data | |
5. | ALA4418845 | B | Inhibition of CUL4B in human MCF7 cells assessed as reduction in 3-methylcholanthrene-induced androgen receptor degradation at 50 uM | Homo sapiens | 11 | ALA4418496 | cell-based format | Patent Bioactivity Data | |
6. | ALA4418846 | B | Inhibition of CUL4A in human HCT116 cells assessed as promotion of UV-damaged DNA repair by measuring enhancement of 6,4-photoproducts removal pre-incubated for 2 hrs before UV-irradiation by ELISA | Homo sapiens | 2 | ALA4418496 | cell-based format | Patent Bioactivity Data | |
7. | ALA4709071 | B | Inhibition of eEF2K (unknown origin) | Homo sapiens | 5 | ALA4706525 | single protein format | Scientific Literature |