# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4433502 | Functional | Agonist activity at rat delta opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding incubated for 1 hr relative to DPDPE | Rattus norvegicus | 25 | ALA4433205 | cell-based format | Scientific Literature | |
2. | ALA4433503 | Functional | Agonist activity at rat mu opioid receptor expressed in rat C6 glioma cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr relative to DAMGO | Rattus norvegicus | 25 | ALA4433205 | cell-based format | Scientific Literature | |
3. | ALA4433504 | Functional | Agonist activity at human kappa opioid receptor expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr | Homo sapiens | 25 | ALA4433205 | cell-based format | Scientific Literature | |
4. | ALA4433505 | Functional | Agonist activity at human kappa opioid receptor expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding to G protein incubated for 1 hr relative to U69,593 | Homo sapiens | 25 | ALA4433205 | cell-based format | Scientific Literature | |
5. | ALA4433506 | Functional | Agonist activity at rat delta opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr | Rattus norvegicus | 25 | ALA4433205 | cell-based format | Scientific Literature | |
6. | ALA4433507 | Functional | Antinociceptive activity in C57BL/6 mouse assessed as increase in latency to tail withdrawal up to 10 mg/kg, ip administered at 30 mins interval measured during compound dosing by warm water tail withdrawal assay relative to control | Mus musculus | 25 | ALA4433205 | organism-based format | Scientific Literature | |
7. | ALA4433508 | Functional | Agonist activity at rat mu opioid receptor expressed in rat C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 1 hr | Rattus norvegicus | 25 | ALA4433205 | cell-based format | Scientific Literature | |
8. | ALA4433509 | Binding | Selectivity ratio of Ki for rat delta opioid receptor expressed in rat C6 cell membranes to Ki for rat mu opioid receptor expressed in rat C6 cell membranes | Rattus norvegicus | 25 | ALA4433205 | cell-based format | Scientific Literature | |
9. | ALA4433510 | Binding | Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membranes measured after 1 hr by liquid scintillation counting method | Homo sapiens | 25 | ALA4433205 | cell-based format | Scientific Literature | |
10. | ALA4433511 | Binding | Displacement of [3H]diprenorphine from rat delta opioid receptor expressed in rat C6 cell membranes measured after 1 hr by liquid scintillation counting method | Rattus norvegicus | 25 | ALA4433205 | cell-based format | Scientific Literature | |
11. | ALA4433512 | Binding | Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cell membranes measured after 1 hr by liquid scintillation counting method | Rattus norvegicus | 25 | ALA4433205 | cell-based format | Scientific Literature | |
12. | ALA4433513 | Functional | Antinociceptive activity in C57BL/6 mouse assessed as increase in latency to tail withdrawal by measuring time of action at 10 mg/kg, ip administered as bolus dose by warm water tail withdrawal assay | Mus musculus | 6 | ALA4433205 | organism-based format | Scientific Literature | |
13. | ALA4433514 | Physicochemical | Lipophilicity, log P of the compound | 30 | ALA4433205 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA4433515 | Functional | Agonist activity at rat delta opioid receptor expressed in C6 cell membranes assessed as stimulation of [35S]GTPgammaS binding at 1 uM incubated for 1 hr relative to SNC80 | Rattus norvegicus | 3 | ALA4433205 | cell-based format | Scientific Literature | |
15. | ALA4433516 | Functional | Antagonist activity at rat delta opioid receptor expressed in rat C6 cell membranes assessed as inhibition of SNC80-induced [35S] GTPgammaS binding measured after 1 hr | Rattus norvegicus | 3 | ALA4433205 | cell-based format | Scientific Literature |