The store will not work correctly when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
The page will load shortly, Thanks for your patience!
# Aladdin ID Assay Type Description Organism Compounds Reference BAO Format Source 1. ALA4311709 Binding Inhibition of human SGLT1 expressed in CHOK1 cells assessed as reduction in sodium-dependent glucose uptake after 30 mins in presence of [14C]-methyl-alpha -D-glucopyranoside by microbeta counting method Homo sapiens 22 ALA4308914 cell-based format Scientific Literature 2. ALA4311710 Binding Inhibition of human SGLT2 expressed in CHOK1 cells assessed as reduction in sodium-dependent glucose uptake after 1 hr in presence of [14C]-methyl-alpha -D-glucopyranoside by microbeta counting method Homo sapiens 22 ALA4308914 cell-based format Scientific Literature 3. ALA4311711 ADME Permeability of the compound at pH 7.4 by PAMPA assay 13 ALA4308914 assay format Scientific Literature 4. ALA4311712 ADME Total clearance in Sprague-Dawley rat at 0.4 mg/kg, iv Rattus norvegicus 2 ALA4308914 organism-based format Scientific Literature 5. ALA4311713 ADME Volume of distribution at steady sate in Sprague-Dawley rat at 0.4 mg/kg, iv Rattus norvegicus 2 ALA4308914 organism-based format Scientific Literature 6. ALA4311714 ADME Half life in Sprague-Dawley rat at 0.4 mg/kg, iv Rattus norvegicus 2 ALA4308914 organism-based format Scientific Literature 7. ALA4311715 ADME Cmax in Sprague-Dawley rat at 30 mg/kg, po Rattus norvegicus 2 ALA4308914 organism-based format Scientific Literature 8. ALA4311716 ADME Tmax in Sprague-Dawley rat at 30 mg/kg, po Rattus norvegicus 2 ALA4308914 organism-based format Scientific Literature 9. ALA4311717 ADME Oral bioavailability in Sprague-Dawley rat at 30 mg/kg Rattus norvegicus 2 ALA4308914 organism-based format Scientific Literature 10. ALA4311719 ADME Drug excretion in bile duct cannulated Sprague-Dawley rat urine at 0.3 mg/kg, iv administered as single dose after 24 hrs by LCMS analysis Rattus norvegicus 2 ALA4308914 organism-based format Scientific Literature 11. ALA4311721 ADME Drug excretion in bile duct cannulated Sprague-Dawley rat bile at 0.3 mg/kg, iv administered as single dose after 24 hrs by LCMS analysis Rattus norvegicus 2 ALA4308914 organism-based format Scientific Literature 12. ALA4311725 ADME Drug uptake in Sprague-Dawley rat kidney at 0.3 mg/kg, iv administered as single dose after 2 hrs by LCMS analysis Rattus norvegicus 3 ALA4308914 organism-based format Scientific Literature 13. ALA4311726 ADME Drug uptake in Sprague-Dawley rat kidney at 0.3 mg/kg, iv administered as single dose after 24 hrs by LCMS analysis Rattus norvegicus 3 ALA4308914 organism-based format Scientific Literature 14. ALA4311727 ADME Drug uptake in Sprague-Dawley rat kidney at 0.3 mg/kg, iv administered as single dose after 72 hrs by LCMS analysis Rattus norvegicus 3 ALA4308914 organism-based format Scientific Literature 15. ALA4311728 ADME Drug uptake in Sprague-Dawley rat kidney assessed as unchanged drug level at 0.3 mg/kg, iv administered as single dose after 72 hrs by LCMS analysis relative to control Rattus norvegicus 3 ALA4308914 organism-based format Scientific Literature