# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4406751 | Binding | Inhibition of human ALK2 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assay | Homo sapiens | 25 | ALA4402613 | single protein format | Scientific Literature | |
2. | ALA4406752 | ADME | Inhibition of human ALK5 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assay | Homo sapiens | 25 | ALA4402613 | single protein format | Scientific Literature | |
3. | ALA4406753 | Binding | Selectivity index, ratio of IC50 for inhibition of human ALK5 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assay to IC50 for inhibition of human ALK3 using casein as substrate in presence of 10 uM [gamma33P] ATP by radioactive assay | Homo sapiens | 20 | ALA4402613 | assay format | Scientific Literature | |
4. | ALA4626169 | Binding | Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assay | Homo sapiens | 29 | ALA4622974 | single protein format | Scientific Literature | |
5. | ALA4626170 | Binding | Selectivity ratio of IC50 for human ALK5 to human ALK2 | Homo sapiens | 29 | ALA4622974 | assay format | Scientific Literature | |
6. | ALA4626171 | ADME | Selectivity ratio of IC50 for human ALK4 to IC50 for human ALK2 | Homo sapiens | 8 | ALA4622974 | assay format | Scientific Literature | |
7. | ALA4626172 | ADME | Inhibition of human ALK4 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assay | Homo sapiens | 10 | ALA4622974 | single protein format | Scientific Literature | |
8. | ALA4626173 | Binding | Inhibition of human ALK2 R206H mutant using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assay | Homo sapiens | 1 | ALA4622974 | single protein format | Scientific Literature | |
9. | ALA4626174 | Binding | Inhibition of ALK2 G328V mutant (unknown origin) by radiometric assay | Homo sapiens | 1 | ALA4622974 | single protein format | Scientific Literature | |
10. | ALA4626179 | Binding | Inhibition of ALK2 R258G mutant (unknown origin) by radiometric hotspot assay | Homo sapiens | 1 | ALA4622974 | single protein format | Scientific Literature | |
11. | ALA4626180 | ADME | Inhibition of human ALK5 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assay | Homo sapiens | 29 | ALA4622974 | single protein format | Scientific Literature | |
12. | ALA4626181 | Binding | Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGlo substrate based NanoBRET assay | Homo sapiens | 29 | ALA4622974 | cell-based format | Scientific Literature | |
13. | ALA4626182 | ADME | Inhibition of recombinant human ALK5 expressed in HEK293 cells transfected with CAGA-luciferase and Renilla luciferase reporter after 24 hrs by dual luciferase reporter assay | Homo sapiens | 29 | ALA4622974 | cell-based format | Scientific Literature | |
14. | ALA4626183 | Binding | Selectivity ratio of IC50 for human ALK5 expressed in HEK293 cells to IC50 for ALK2 (unknown origin) expressed in HEK293 cells | Homo sapiens | 29 | ALA4622974 | cell-based format | Scientific Literature | |
15. | ALA4626184 | Binding | Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 G328V mutant (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGlo substrate based NanoBRET assay | Homo sapiens | 1 | ALA4622974 | cell-based format | Scientific Literature | |
16. | ALA4626185 | Binding | Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 G356D mutant (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGlo substrate based NanoBRET assay | Homo sapiens | 1 | ALA4622974 | cell-based format | Scientific Literature | |
17. | ALA4626186 | Binding | Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 Q207D mutant (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGlo substrate based NanoBRET assay | Homo sapiens | 1 | ALA4622974 | cell-based format | Scientific Literature | |
18. | ALA4626187 | Binding | Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 R206H mutant (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGlo substrate based NanoBRET assay | Homo sapiens | 1 | ALA4622974 | cell-based format | Scientific Literature | |
19. | ALA4626188 | ADME | Inhibition of human ALK1 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assay | Homo sapiens | 1 | ALA4622974 | single protein format | Scientific Literature | |
20. | ALA4626189 | ADME | Inhibition of human ALK3 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assay | Homo sapiens | 1 | ALA4622974 | single protein format | Scientific Literature |