#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4346466	Binding	Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) assessed as relative fluorescence intensity incubated for 4 hrs by 8-NBD-cAMP competition binding assay relative to control	Homo sapiens	57	ALA4342525	assay format	Scientific Literature
2.	ALA4346467	Binding	Binding affinity to GST-tagged recombinant EPAC1 CNBD (169 to 318 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) incubated for 4 hrs by 8-NBD-cAMP competition binding assay	Homo sapiens	6	ALA4342525	assay format	Scientific Literature
3.	ALA4346468	Binding	Binding affinity to GST-tagged recombinant EPAC1 delta-DEP mutant (149 to 881 residues) (unknown origin) expressed in Escherichia coli BL21 Star (DE3) incubated for 4 hrs by 8-NBD-cAMP competition binding assay	Homo sapiens	4	ALA4342525	assay format	Scientific Literature
4.	ALA4346469	Binding	Activation of recombinant EPAC1 (149 to 881 residues) (unknown origin) assessed as stimulation of dissociation of fluorescent MANT-GDP from recombinant Rap1b at 500 uM in presence of excess nonfluorescent nucleotides by fluorescence based in-vitro GEF assay relative to cAMP	Homo sapiens	2	ALA4342525	single protein format	Scientific Literature
5.	ALA4346470	Binding	Activity at recombinant EPAC1 (149 to 881 residues) (unknown origin) assessed as reduction in cAMP-induced stimulation of dissociation of fluorescent MANT-GDP from recombinant Rap1b at 500 uM in presence of excess nonfluorescent nucleotides by fluorescence based in-vitro GEF assay	Homo sapiens	2	ALA4342525	single protein format	Scientific Literature
6.	ALA4346471	Binding	Activation of recombinant EPAC1 (149 to 881 residues) (unknown origin) assessed as stimulation of dissociation of fluorescent MANT-GDP from recombinant Rap1b in presence of excess nonfluorescent nucleotides by fluorescence based in-vitro GEF assay	Homo sapiens	3	ALA4342525	single protein format	Scientific Literature
7.	ALA4346473	Binding	Activation of EPAC1 (unknown origin) expressed in U2OS cells at 100 uM pre-incubated for 10 mins before 8-pCPT-2'-O-Me-cAMP stimulation for 10 mins using GST-RalGDS-RBD by Western blot analysis based active GTP-bound Rap1 pull down assay	Homo sapiens	3	ALA4342525	cell-based format	Scientific Literature
8.	ALA4346474	Binding	Activation of recombinant EPAC1 (149 to 881 residues) (unknown origin) assessed as stimulation of dissociation of fluorescent MANT-GDP from recombinant Rap1b at 10 uM in presence of excess nonfluorescent nucleotides by fluorescence based in-vitro GEF assay relative to cAMP	Homo sapiens	6	ALA4342525	single protein format	Scientific Literature
9.	ALA4346475	ADME	Activation of PKA in human U2OS cells stably transfected with EPAC1 assessed as increase in VASP phosphorylation at 100 uM by Western blot analysis	Homo sapiens	6	ALA4342525	cell-based format	Scientific Literature
10.	ALA4346476	Binding	Activation of EPAC1 (unknown origin) expressed in U2OS cells at 100 uM incubated for 10 mins using GST-RalGDS-RBD by Western blot analysis based active GTP-bound Rap1 pull down assay	Homo sapiens	6	ALA4342525	cell-based format	Scientific Literature
11.	ALA4346477	Binding	Activation of EPAC1 in HUVEC assessed as reduction in IL-6-promoted signaling by measuring pSTAT3 protein levels at 100 uM pre-incubated for 30 mins before IL6 and sIL6Ralpha stimulation for 5 hrs by Western blotting analysis	Homo sapiens	5	ALA4342525	cell-based format	Scientific Literature
12.	ALA4346478	Binding	Activation of EPAC1 in HUVEC assessed as reduction in IL-6-promoted signaling by measuring pERK protein levels at 100 uM pre-incubated for 30 mins before IL6 and sIL6Ralpha stimulation for 5 hrs by Western blotting analysis	Homo sapiens	5	ALA4342525	cell-based format	Scientific Literature
13.	ALA4346479	Binding	Activation of EPAC1 in HUVEC assessed as reduction in IL-6-promoted signaling by measuring pAKT protein levels at 100 uM pre-incubated for 30 mins before IL6 and sIL6Ralpha stimulation for 5 hrs by Western blotting analysis	Homo sapiens	3	ALA4342525	cell-based format	Scientific Literature
14.	ALA4346480	Binding	Activation of EPAC1 in HUVEC assessed as reduction in IL-6-promoted signaling by measuring VCAM1 protein expression at 100 uM pre-incubated for 30 mins before IL6 and sIL6Ralpha stimulation for 5 hrs by Western blotting analysis	Homo sapiens	5	ALA4342525	cell-based format	Scientific Literature
15.	ALA4346481	Binding	Activation of EPAC1 in HUVEC assessed as reduction in IL-6-promoted signaling by measuring ICAM1 protein expression at 100 uM pre-incubated for 30 mins before IL6 and sIL6Ralpha stimulation for 5 hrs by Western blotting analysis	Homo sapiens	4	ALA4342525	cell-based format	Scientific Literature
16.	ALA4346482	Binding	Activation of EPAC1 in HUVEC assessed as reduction in IL-6-promoted signaling by measuring SELE protein expression at 100 uM pre-incubated for 30 mins before IL6 and sIL6Ralpha stimulation for 5 hrs by Western blotting analysis	Homo sapiens	4	ALA4342525	cell-based format	Scientific Literature