# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4372229 | B | Inhibition of recombinant human pro-MMP1 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs followed by substrate addition and measured every 10 secs for 15 mins in presence of APMA by fluorometric assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
2. | ALA4372230 | B | Inhibition of recombinant human proMMP2 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs followed by substrate addition and measured every 10 secs for 15 mins in presence of APMA by fluorometric assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
3. | ALA4372231 | B | Inhibition of recombinant human proMMP9 using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs followed by substrate addition and measured every 10 secs for 15 mins in presence of APMA by fluorometric assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
4. | ALA4372232 | B | Inhibition of recombinant human MT1-MMP catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated for 3 hrs followed by substrate addition and measured every 10 secs for 15 min by fluorometric assay | Homo sapiens | 7 | single protein format | Scientific Literature | ||
5. | ALA4372233 | P | Aqueous solubility of the compound | 1 | small-molecule physicochemical format | Scientific Literature | |||
6. | ALA4372234 | A | Cytotoxicity against human HT1080 cells at 10 to 50 uM after 4 hrs by MTS assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
7. | ALA4372237 | B | Inhibition of MT1-MMP-mediated proMMP-2 activation in human HT1080 cells stimulated with type I collagen for 24 hrs followed by compound addition at 1 to 10 uM and measured after 24 hrs by gelatin zymography assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
8. | ALA4372238 | B | Inhibition of MT1-MMP-mediated proMMP-2 activation in human HT1080 cells stimulated with type I collagen for 24 hrs followed by compound addition assessed as increase in proMT1-MMP (65 KDa) level at 1 to 10 uM and measured after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
9. | ALA4372239 | B | Inhibition of MT1-MMP mediated collagenolytic activity in human HT1080 cells stimulated with type I collagen for 48 hrs followed by compound addition at 1 to 10 uM and measured after 48 hrs by Coomassie Blue staining-based collagen film degradation assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
10. | ALA4372240 | B | Inhibition of MT1-MMP-mediated collagen invasion in human HT1080 cells attached to gelatin-coated Cytodex 3 microcarrier beads assessed as cell migration out from the bead surface into collagen matrix at 1 to 10 uM and measured after overnight incubation by microcarriers beads invasion assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
11. | ALA4372241 | B | Inhibition of MT1-MMP-mediated proMMP-2 activation in human HT1080 cells stimulated with type I collagen for 24 hrs followed by compound addition at <0.1 uM and measured after 24 hrs by gelatin zymography assay | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
12. | ALA4372244 | B | Inhibition of MT1-MMP-mediated proMMP-2 activation in human HT1080 cells stimulated with type I collagen for 24 hrs followed by compound addition assessed as increase in active MT1-MMP (55 KDa) level at 1 to 10 uM and measured after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
13. | ALA4372247 | B | Inhibition of MT1-MMP-mediated proMMP-2 activation in human HT1080 cells stimulated with type I collagen for 24 hrs followed by compound addition assessed as increase in proMT1-MMP (65 KDa) level at 0.01 to 10 uM and measured after 24 hrs by Western blot analysis | Homo sapiens | 2 | cell-based format | Scientific Literature |