# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4397302 | B | Chaperone activity at Lysosomal alpha-mannosidase in wild-type human fibroblasts assessed as increase in Lysosomal alpha-mannosidase activity at 0.2 to 20 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 6 | ALA4396870 | single protein format | Scientific Literature | |
2. | ALA4397303 | B | Chaperone activity at Lysosomal alpha-mannosidase in wild-type human fibroblasts assessed as increase in Lysosomal alpha-mannosidase activity using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method | Homo sapiens | 6 | ALA4396870 | single protein format | Scientific Literature | |
3. | ALA4397304 | B | Inhibition of Lysosomal alpha-mannosidase in wild-type human fibroblast cell lysates using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 60 mins by fluorescence method | Homo sapiens | 7 | ALA4396870 | subcellular format | Scientific Literature | |
4. | ALA4397306 | B | Inhibition of bovine liver beta-glucosidase assessed as residual hydrolytic activity after 10 to 30 mins by spectrophotometric analysis | Bos taurus | 8 | ALA4396870 | assay format | Scientific Literature | |
5. | ALA4397308 | B | Inhibition of jack bean Lysosomal alpha-mannosidase assessed as residual hydrolytic activity after 10 to 30 mins by spectrophotometric analysis | Canavalia ensiformis | 8 | ALA4396870 | single protein format | Scientific Literature | |
6. | ALA4397317 | B | Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as increase in Lysosomal alpha-mannosidase activity using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method | Homo sapiens | 5 | ALA4396870 | single protein format | Scientific Literature | |
7. | ALA4397318 | B | Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as increase in Lysosomal alpha-mannosidase activity at 20 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 4 | ALA4396870 | single protein format | Scientific Literature | |
8. | ALA4397322 | B | Chaperone activity at Lysosomal alpha-mannosidase P356R mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as increase in Lysosomal alpha-mannosidase activity at 2 to 20 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 6 | ALA4396870 | single protein format | Scientific Literature | |
9. | ALA4397324 | B | Chaperone activity at Lysosomal alpha-mannosidase R750W mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as Lysosomal alpha-mannosidase activity at 2 uM using 4-methylumbelliferone alpha-D-mannopyranoside as a reporter substrate incubated for 4 days by fluorescence method relative to control | Homo sapiens | 4 | ALA4396870 | single protein format | Scientific Literature | |
10. | ALA4397326 | B | Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts lysosome derived from alpha-Mannosidosis patient assessed as enzyme activity enhancement at 20 uM incubated for 96 hrs by sub-cellular fractionation analysis relative to control | Homo sapiens | 1 | ALA4396870 | single protein format | Scientific Literature | |
11. | ALA4397328 | B | Chaperone activity at Lysosomal alpha-mannosidase H72L mutant in human fibroblasts derived from alpha-Mannosidosis patient assessed as reduction in cholesterol accumulation at 0.2 uM incubated for 96 hrs by Amplex red cholesterol assay relative to wild-type control | Homo sapiens | 3 | ALA4396870 | single protein format | Scientific Literature | |
12. | ALA4397329 | A | Chaperone activity at Lysosomal alpha-mannosidase in human fibroblasts assessed as reduction in cholesterol accumulation at 0.2 uM incubated for 96 hrs by Amplex red cholesterol assay | Homo sapiens | 3 | ALA4396870 | single protein format | Scientific Literature | |
13. | ALA4397330 | B | Chaperone activity at human Lysosomal alpha-mannosidase C55F mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 0.2 uM incubated for 96 hrs relative to control | Homo sapiens | 2 | ALA4396870 | assay format | Scientific Literature | |
14. | ALA4397331 | B | Chaperone activity at human Lysosomal alpha-mannosidase C55F mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 2 uM incubated for 96 hrs relative to control | Homo sapiens | 2 | ALA4396870 | assay format | Scientific Literature | |
15. | ALA4397332 | B | Chaperone activity at human Lysosomal alpha-mannosidase C55F mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 20 uM incubated for 96 hrs relative to control | Homo sapiens | 2 | ALA4396870 | assay format | Scientific Literature | |
16. | ALA4397333 | B | Chaperone activity at human Lysosomal alpha-mannosidase H72L mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 0.2 uM incubated for 96 hrs relative to control | Homo sapiens | 2 | ALA4396870 | assay format | Scientific Literature | |
17. | ALA4397334 | B | Chaperone activity at human Lysosomal alpha-mannosidase H72L mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 2 uM incubated for 96 hrs relative to control | Homo sapiens | 2 | ALA4396870 | assay format | Scientific Literature | |
18. | ALA4397335 | B | Chaperone activity at human Lysosomal alpha-mannosidase H72L mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 20 uM incubated for 96 hrs relative to control | Homo sapiens | 2 | ALA4396870 | assay format | Scientific Literature | |
19. | ALA4397336 | B | Chaperone activity at human Lysosomal alpha-mannosidase L352P mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 0.2 uM incubated for 96 hrs relative to control | Homo sapiens | 2 | ALA4396870 | assay format | Scientific Literature | |
20. | ALA4397337 | B | Chaperone activity at human Lysosomal alpha-mannosidase L352P mutant transfected in human MAN21B knockout HAP1 cells assessed as enzyme activity enhancement at 2 uM incubated for 96 hrs relative to control | Homo sapiens | 2 | ALA4396870 | assay format | Scientific Literature |