| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4361953 | Binding | Inhibition of human placental microsomal fraction 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis | Homo sapiens | 23 | ALA4359859 | subcellular format | Scientific Literature | |
| 2. | ALA4361954 | Binding | Inhibition of human placental cytosolic fraction 17beta-HSD1 using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysis | Homo sapiens | 22 | ALA4359859 | assay format | Scientific Literature | |
| 3. | ALA4361955 | Binding | Selectivity ratio of IC50 for human placental cytosolic fraction 17beta-HSD1 to IC50 for human placental microsomal fraction 17beta-HSD2 | Homo sapiens | 23 | ALA4359859 | assay format | Scientific Literature | |
| 4. | ALA4361956 | Binding | Inhibition of mouse liver homogenate 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis | Mus musculus | 15 | ALA4359859 | tissue-based format | Scientific Literature | |
| 5. | ALA4361958 | Binding | Inhibition of recombinant mouse 17beta-HSD1 expressed in HEK293 cells at 1 uM using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysis relative to control | Mus musculus | 22 | ALA4359859 | cell-based format | Scientific Literature | |
| 6. | ALA4361959 | ADME | Half life in human liver S9 fraction at 1 uM measured in presence of NADPH generating system | Homo sapiens | 23 | ALA4359859 | subcellular format | Scientific Literature | |
| 7. | ALA4361960 | ADME | Half life in mouse liver S9 fraction at 1 uM measured in presence of NADPH generating system | Mus musculus | 10 | ALA4359859 | subcellular format | Scientific Literature | |
| 8. | ALA4361961 | Physicochemical | Aqueous solubility of the compound in pH 7.2 phosphate buffered saline/DMSO | 23 | ALA4359859 | small-molecule physicochemical format | Scientific Literature | ||
| 9. | ALA4361962 | ADME | Cytotoxicity against HEK293 cells assessed as reduction in cell viability measured after 66 hrs by MTT assay | Homo sapiens | 4 | ALA4359859 | cell-based format | Scientific Literature | |
| 10. | ALA4361963 | Unassigned | Selectivity ratio of IC50 for HEK293 cells to IC50 for human placental microsomal fraction 17beta-HSD2 | Homo sapiens | 4 | ALA4359859 | assay format | Scientific Literature | |
| 11. | ALA4361964 | Binding | Inhibition of 17beta-HSD2 in human MDA-MB-231 cells using [3H]-E2 as substrate after 6 hrs by radio-HPLC analysis | Homo sapiens | 4 | ALA4359859 | cell-based format | Scientific Literature | |
| 12. | ALA4361965 | Binding | Selectivity ratio of IC50 for 17beta-HSD2 in human MDA-MB-231 to IC50 for human placental microsomal fraction 17beta-HSD2 | Homo sapiens | 4 | ALA4359859 | assay format | Scientific Literature | |
| 13. | ALA4361966 | ADME | Time at which plasma concentration stays at in vitro IC50 for mouse liver homogenate 17beta-HSD2 in C57BL/6N mouse at 50 mg/kg, po by HPLC-LC/MS analysis | Mus musculus | 5 | ALA4359859 | organism-based format | Scientific Literature | |
| 14. | ALA4361967 | Binding | Inhibition of rat liver homogenate 17beta-HSD2 using [3H]-E2 as substrate in presence of NAD+ by radio-HPLC analysis | Rattus norvegicus | 4 | ALA4359859 | tissue-based format | Scientific Literature | |
| 15. | ALA4361968 | Binding | Inhibition of recombinant rat 17beta-HSD1 expressed in HEK293 cells using [3H]-E1 as substrate in presence of NAD+ by radio-HPLC analysis | Rattus norvegicus | 4 | ALA4359859 | cell-based format | Scientific Literature | |
| 16. | ALA4361969 | ADME | Half life in rat liver S9 fraction at 1 uM measured in presence of NADPH generating system | Rattus norvegicus | 4 | ALA4359859 | subcellular format | Scientific Literature | |
| 17. | ALA4361971 | Binding | Agonist activity at ERalpha (unknown origin) expressed in human U2OS cells at 10 uM measured after 24 hrs by dual luciferase reporter gene assay relative to control | Homo sapiens | 3 | ALA4359859 | cell-based format | Scientific Literature | |
| 18. | ALA4361972 | ADME | Antagonist activity at ERalpha (unknown origin) expressed in human U2OS cells assessed as inhibition of E2-induced transcriptional activity at 10 uM measured after 24 hrs by dual luciferase reporter gene assay relative to control | Homo sapiens | 3 | ALA4359859 | cell-based format | Scientific Literature | |
| 19. | ALA4361973 | ADME | Plasma concentration in Wistar Hannover RjHan:Wi rat at 50 mg/kg, po measured after 24 hrs by HPLC-LC/MS analysis | Rattus norvegicus | 1 | ALA4359859 | organism-based format | Scientific Literature | |
| 20. | ALA4361974 | ADME | Ratio of plasma concentration in Wistar Hannover RjHan:Wi rat at 50 mg/kg, po to IC50 for rat liver homogenate 17beta-HSD2 | Rattus norvegicus | 1 | ALA4359859 | organism-based format | Scientific Literature |
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