| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4332053 | B | Modulation of Cluc-FGF14 (unknown origin)/CD4-Nav1.6-Nluc (unknown origin) protein-protein interaction using FGF14/NAV1.6 using HEK293 cells expressing FGF14/Nav1.6 assessed as luminescent response at 50 uM by split luciferase complementation assay relative to control | Homo sapiens | 7 | cell-based format | Scientific Literature | ||
| 2. | ALA4332054 | B | Effect on firefly luciferase activity expressed in HEK293 cells at 50 uM by luminescence assay | Photinus pyralis | 7 | cell-based format | Scientific Literature | ||
| 3. | ALA4332055 | B | Inhibition of Cluc-FGF14 (unknown origin)/CD4-Nav1.6-Nluc (unknown origin) protein-protein interaction using FGF14/NAV1.6 using HEK293 cells expressing FGF14/Nav1.6 by split luciferase complementation assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 4. | ALA4332056 | A | Cytotoxicity against HEK293 cells assessed as reduction in cell viability at 50 uM by LDH release assay | Homo sapiens | 4 | cell-based format | Scientific Literature | ||
| 5. | ALA4332057 | B | Inhibition of Nav1.6 (unknown origin) expressed in HEK293 cells assessed as transient sodium current derived peak density at 10 uM after 1 hr at -70 mV holding potential by whole cell patch clamp method (Rvb = 54.88 +/- 7.4 pA/pF) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4332058 | B | Inhibition of Nav1.6 (unknown origin) expressed in HEK293 cells assessed as depolarizing shift of channel voltage dependence of activation by measuring half activation potential at 10 uM after 1 hr at -70 mV holding potential by whole cell patch clamp method (Rvb = 26.37 +/- 1.5 mV) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4332059 | B | Inhibition of Nav1.6 (unknown origin) expressed in HEK293 cells assessed as activation constant at 10 uM after 1 hr at -70 mV holding potential by whole cell patch clamp method (Rvb = 3.4 +/- 0.2 mV) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4332060 | B | Inhibition of Nav1.6 (unknown origin) expressed in HEK293 cells assessed as V1/2 of steady-state of inactivation at 10 uM after 1 hr at -70 mV holding potential by whole cell patch clamp method (Rvb = 58.12 +/- 0.8 mV) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4332061 | B | Inhibition of Nav1.6 (unknown origin) expressed in HEK293 cells assessed as inactivation constant at 10 uM after 1 hr at -70 mV holding potential by whole cell patch clamp method (Rvb = 6.25 +/- 0.5 mV) | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4332062 | B | Inhibition of Nav1.6 (unknown origin) expressed in HEK293 cells assessed as inactivation time constant at 10 uM after 1 hr at -70 mV holding potential by whole cell patch clamp method (Rvb = 2.04 +/- 0.3 milliseconds) | Homo sapiens | 1 | cell-based format | Scientific Literature |
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