#	Aladdin ID	Assay Type	Description	Organism	Compounds	Reference	BAO Format	Source
1.	ALA4421312	Binding	Inhibition of GST-tagged SOS1 (564 to 1049 amino acids) (unknown origin) assessed as reduction SOS1/6xHis-Tev-tagged K-Ras G12D mutant (1 to 169 residues) interaction incubated for 30 mins by AlphaLISA method	Homo sapiens	214	ALA4420081	single protein format	Patent Bioactivity Data
2.	ALA4421313	Functional	Induction of apoptosis in human NCI-H358 cells grown under 3D anchorage-independent soft-agar conditions at grown under 3D anchorage-independent soft-agar conditions assessed as induction of PARP cleavage at 1 uM in presence of 125 nM of afatinib incubated for 24 hrs by mesoscale assay	Homo sapiens	1	ALA4420081	cell-based format	Patent Bioactivity Data
3.	ALA4421314	Binding	Inhibition of SOS1 in human MIAPaCa2 cells grown under 3D anchorage-independent soft-agar conditions at assessed as ERK1/2 phosphorylation at Thr202/Tyr204 residues at 1 uM in presence of 50 nM trametinib incubated for 2 to 8 hrs by Western blotting analysis relative to control	Homo sapiens	1	ALA4420081	cell-based format	Patent Bioactivity Data
4.	ALA4421315	Functional	Induction of apoptosis in human NCI-H358 cells grown under 3D anchorage-independent soft-agar conditions at grown under 3D anchorage-independent soft-agar conditions assessed as induction of PARP cleavage at 1 uM incubated for 24 to 72 hrs by mesoscale assay	Homo sapiens	1	ALA4420081	cell-based format	Patent Bioactivity Data
5.	ALA4421319	Binding	Inhibition of SOS1 in human MIAPaCa2 cells grown under 3D anchorage-independent soft-agar conditions at assessed as suppression of increase in MEK1/2 phosphorylation at Ser 217/221 residues at 1 uM in presence of 25 to 50 nM trametinib incubated for 2 to 8 hrs by Western blotting analysis	Homo sapiens	1	ALA4420081	cell-based format	Patent Bioactivity Data
6.	ALA4421320	Functional	Antitumor activity against human MIAPaCa2 cells grown under 3D anchorage-independent soft-agar conditions at xenografted in BomTacNMRI-Foxn1 nu mouse assessed as inhibition of tumor growth at 50 mg/kg, po BID relative to control	Homo sapiens	1	ALA4420081	organism-based format	Patent Bioactivity Data
7.	ALA4421321	Functional	Antitumor activity against human MIAPaCa2 cells grown under 3D anchorage-independent soft-agar conditions at xenografted in BomTacNMRI-Foxn1 nu mouse assessed as inhibition of tumor regression at 50 mg/kg, po BID relative to control	Homo sapiens	1	ALA4420081	organism-based format	Patent Bioactivity Data
8.	ALA4421326	Functional	Antitumor activity against human MIAPaCa2 cells grown under 3D anchorage-independent soft-agar conditions at xenografted in BomTacNMRI-Foxn1 nu mouse assessed as inhibition of tumor growth at 50 mg/kg, po BID co-treated with 0.05 mg/kg, po BID trametinib relative to control	Homo sapiens	1	ALA4420081	organism-based format	Patent Bioactivity Data
9.	ALA4421327	Functional	Antitumor activity against human MIAPaCa2 cells grown under 3D anchorage-independent soft-agar conditions at xenografted in BomTacNMRI-Foxn1 nu mouse assessed as inhibition of tumor growth at 50 mg/kg, po BID co-treated with 0.125 mg/kg, po BID trametinib relative to control	Homo sapiens	1	ALA4420081	organism-based format	Patent Bioactivity Data
10.	ALA4421328	Functional	Antitumor activity against human MIAPaCa2 cells grown under 3D anchorage-independent soft-agar conditions at xenografted in BomTacNMRI-Foxn1 nu mouse assessed as inhibition of tumor regression at 50 mg/kg, po BID co-treated with 0.125 mg/kg, po BID trametinib relative to control	Homo sapiens	1	ALA4420081	organism-based format	Patent Bioactivity Data
11.	ALA4421329	Functional	Induction of apoptosis in human A549 cells grown under 3D anchorage-independent soft-agar conditions at grown under 3D anchorage-independent soft-agar conditions assessed as induction of PARP cleavage at 1 uM in presence of 10 nM of paclitaxel incubated for 24 to 48 hrs by mesoscale assay	Homo sapiens	1	ALA4420081	cell-based format	Patent Bioactivity Data
12.	ALA4421330	Toxicity	Toxicity in BomTacNMRI-Foxn1 nu mouse xenografted with human MIAPaCa2 cells grown under 3D anchorage-independent soft-agar conditions at assessed as drug tolerability at 50 mg/kg, po BID co-treated with 10 mg/kg, iv paclitaxel dosed in q7d regime	Mus musculus	1	ALA4420081	organism-based format	Patent Bioactivity Data
13.	ALA4421331	Functional	Antitumor activity against human MIAPaCa2 cells grown under 3D anchorage-independent soft-agar conditions at xenografted in BomTacNMRI-Foxn1 nu mouse assessed as inhibition of tumor growth at 50 mg/kg, po BID co-treated with 10 mg/kg, iv paclitaxel dosed in q7d regime relative to control	Homo sapiens	1	ALA4420081	organism-based format	Patent Bioactivity Data
14.	ALA4421334	Toxicity	Toxicity in BomTacNMRI-Foxn1 nu mouse xenografted with human MIAPaCa2 cells grown under 3D anchorage-independent soft-agar conditions at assessed as drug tolerability at 12 mg/kg, po BID co-treated with 50 mg/kg, ip gemcitabine dosed in q4d regime	Mus musculus	1	ALA4420081	organism-based format	Patent Bioactivity Data
15.	ALA4421335	Functional	Antitumor activity against human MIAPaCa2 cells grown under 3D anchorage-independent soft-agar conditions at xenografted in BomTacNMRI-Foxn1 nu mouse assessed as inhibition of tumor growth at 12 mg/kg, po BID co-treated with 50 mg/kg, ip gemcitabine dosed in q4d regime relative to control	Homo sapiens	1	ALA4420081	organism-based format	Patent Bioactivity Data
16.	ALA4421337	Functional	Antitumor activity against human MIAPaCa2 cells grown under 3D anchorage-independent soft-agar conditions at xenografted in BomTacNMRI-Foxn1 nu mouse assessed as inhibition of tumor growth at 12 mg/kg, po BID relative to control	Homo sapiens	1	ALA4420081	organism-based format	Patent Bioactivity Data
17.	ALA4421342	Functional	Growth inhibition of human PC9 cells grown under 3D anchorage-independent soft-agar conditions at 61.7 nM incubated for 14 days in presence of 1 nM Afatinib by alamar blue dye based assay relative to control	Homo sapiens	1	ALA4420081	cell-based format	Patent Bioactivity Data
18.	ALA4421343	Functional	Growth inhibition of human PC9 cells grown under 3D anchorage-independent soft-agar conditions at 61.7 nM incubated for 14 days in presence of 0.333 nM Afatinib by alamar blue dye based assay relative to control	Homo sapiens	1	ALA4420081	cell-based format	Patent Bioactivity Data
19.	ALA4421344	Functional	Growth inhibition of human PC9 cells grown under 3D anchorage-independent soft-agar conditions at 61.7 nM incubated for 14 days in presence of 0.111 nM Afatinib by alamar blue dye based assay relative to control	Homo sapiens	1	ALA4420081	cell-based format	Patent Bioactivity Data
20.	ALA4421345	Functional	Growth inhibition of human PC9 cells grown under 3D anchorage-independent soft-agar conditions at 61.7 nM incubated for 14 days in presence of 0.037 nM Afatinib by alamar blue dye based assay relative to control	Homo sapiens	1	ALA4420081	cell-based format	Patent Bioactivity Data