# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4363567 | Functional | Antiviral activity against DENV-2 infected in human A549 or Mesocricetus auratus BHK21 cells preincubated for 30 mins further incubated for 1 hr followed by replacement of fresh medium containing compounds and measured at 8 hrs post infection by renilla luciferase assay | dengue virus type 2 | 30 | ALA4359909 | organism-based format | Scientific Literature | |
2. | ALA4363568 | ADME | Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay | Homo sapiens | 30 | ALA4359909 | cell-based format | Scientific Literature | |
3. | ALA4363569 | Toxicity | Selectivity index, ratio of CC50 for human A549 or Mesocricetus auratus BHK21 cells to EC50 for antiviral activity against DENV-2 infected in A549or Mesocricetus auratus BHK21 cells | 30 | ALA4359909 | assay format | Scientific Literature | ||
4. | ALA4363570 | Functional | Antiviral activity against DENV-1 Hawaii infected in African green monkey Vero cells assessed as virus yield reduction after 48 hrs by crystal violet staining based plaque assay | dengue virus type 1 | 2 | ALA4359909 | organism-based format | Scientific Literature | |
5. | ALA4363571 | Functional | Antiviral activity against DENV-2 New Guinea C infected in African green monkey Vero cells assessed as virus yield reduction after 48 hrs by crystal violet staining based plaque assay | dengue virus type 2 | 2 | ALA4359909 | organism-based format | Scientific Literature | |
6. | ALA4363572 | Functional | Antiviral activity against DENV-3 H87 infected in African green monkey Vero cells assessed as virus yield reduction after 48 hrs by crystal violet staining based plaque assay | dengue virus type 3 | 2 | ALA4359909 | organism-based format | Scientific Literature | |
7. | ALA4363573 | Functional | Antiviral activity against DENV-4 8124 infected in African green monkey Vero cells assessed as virus yield reduction after 48 hrs by crystal violet staining based plaque assay | dengue virus type 4 | 2 | ALA4359909 | organism-based format | Scientific Literature | |
8. | ALA4363574 | Physicochemical | Solubility in simulated gastric fluid at 1 mg incubated for 24 hrs in shaker and measured after 24 hrs by shake-flask method based UV-VIS-NIR spectrophotometric analysis | 2 | ALA4359909 | small-molecule physicochemical format | Scientific Literature | ||
9. | ALA4363575 | Physicochemical | Solubility in simulated intestinal fluid at 1 mg incubated for 24 hrs in shaker and measured after 24 hrs by shake-flask method based UV-VIS-NIR spectrophotometric analysis | 2 | ALA4359909 | small-molecule physicochemical format | Scientific Literature | ||
10. | ALA4363576 | Physicochemical | Solubility in PBS at 1 mg incubated for 24 hrs in shaker and measured after 24 hrs by shake-flask method based UV-VIS-NIR spectrophotometric analysis | 2 | ALA4359909 | small-molecule physicochemical format | Scientific Literature | ||
11. | ALA4363577 | ADME | Half life in simulated gastric fluid at 50 uM measured up to 120 mins at pH 1.2 by HPLC-MS analysis | 2 | ALA4359909 | assay format | Scientific Literature | ||
12. | ALA4363578 | ADME | Half life in simulated intestinal fluid at 50 uM measured up to 120 mins at pH 6.8 by HPLC-MS analysis | 2 | ALA4359909 | assay format | Scientific Literature | ||
13. | ALA4363579 | Physicochemical | Half life in PBS at 50 uM measured up to 120 mins at pH 7.4 by HPLC-MS analysis | 2 | ALA4359909 | small-molecule physicochemical format | Scientific Literature | ||
14. | ALA4363580 | ADME | Half life in mouse plasma at 50 uM measured up to 120 mins by HPLC-MS analysis | Mus musculus | 2 | ALA4359909 | cell-free format | Scientific Literature | |
15. | ALA5109274 | Functional | Antiviral activity against DENV infected in human A549 cells assessed as inhibition of virus induced cytopathic effect pre-incubated with virus for 30 mins followed by infection with cells measured after 8 to 24 hrs by luciferase activity assay | Dengue virus | 6 | ALA5107980 | organism-based format | Scientific Literature | |
16. | ALA5109275 | Toxicity | Cytotoxicity against human A549 cells assessed as cell growth inhibition after 48 hrs by MTT assay | Homo sapiens | 5 | ALA5107980 | cell-based format | Scientific Literature | |
17. | ALA5109276 | Toxicity | Selectivity Index, ratio of CC50 for human A549 cells to EC50 for antiviral activity against DENV infected in human A549 cells | 5 | ALA5107980 | cell-based format | Scientific Literature | ||
18. | ALA5109277 | Functional | Antiviral activity against DENV1 (Hawaii) infected in African green monkey Vero cells assessed as inhibition of virus induced cytopathic effect by crystal violet staining based plaque assay | dengue virus type 1 | 2 | ALA5107980 | organism-based format | Scientific Literature | |
19. | ALA5109278 | Functional | Antiviral activity against DENV2 (New Guinea C) infected in African green monkey Vero cells assessed as inhibition of virus induced cytopathic effect by crystal violet staining based plaque assay | dengue virus type 2 | 2 | ALA5107980 | organism-based format | Scientific Literature | |
20. | ALA5109279 | Functional | Antiviral activity against DENV3 (H87) infected in African green monkey Vero cells assessed as inhibition of virus induced cytopathic effect by crystal violet staining based plaque assay | dengue virus type 3 | 2 | ALA5107980 | organism-based format | Scientific Literature |