| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA728410 | F | In vivo average survival rate of mouse infected by T.b. rhodesiense was determined for a period of 60 days at dose of 75 mg/kg by p.o. administration | Mus musculus | 2 | organism-based format | Scientific Literature | ||
| 2. | ALA734015 | F | No. of mice that survived T.b. rhodesiense infection and are parasite free for 60 days was determined at dose of 75 mg/kg by p.o. administration; 4 animals tested | Mus musculus | 3 | organism-based format | Scientific Literature | ||
| 3. | ALA753458 | F | In vitro inhibitory activity against Plasmodium falciparum | Plasmodium falciparum | 19 | organism-based format | Scientific Literature | ||
| 4. | ALA759894 | B | In vitro binding affinity towards Poly (dA-dT)2 | 11 | nucleic acid format | Scientific Literature | |||
| 5. | ALA812088 | F | In vitro inhibitory activity against T. b. rhodesiense | Trypanosoma brucei rhodesiense | 20 | organism-based format | Scientific Literature | ||
| 6. | ALA1654308 | F | Antitrypanosomal activity against wild-type Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as cure from infection at 75 mg/kg, po for 4 days | Trypanosoma brucei rhodesiense | 1 | organism-based format | Scientific Literature | ||
| 7. | ALA1654312 | F | Antitrypanosomal activity against wild-type Trypanosoma brucei rhodesiense STIB900 infected in NMRI mouse assessed as survival of mouse at 75 mg/kg, po for 4 days | Trypanosoma brucei rhodesiense | 1 | organism-based format | Scientific Literature | ||
| 8. | ALA3539595 | A | Prodrug conversion in human liver microsomes assessed as elution time treated with 10 uM DB868 after 180 mins incubation by HPLC-UV chromatography | Homo sapiens | 5 | assay format | Scientific Literature | ||
| 9. | ALA3536991 | A | Drug level in human liver microsomes treated with 10 uM DB868 prodrug after 180 mins incubation by HPLC-UV chromatography relative to initial prodrug concentration | Homo sapiens | 4 | assay format | Scientific Literature | ||
| 10. | ALA3536992 | A | Drug level in rat liver microsomes treated with 10 uM DB868 prodrug after 180 mins incubation by HPLC-UV chromatography relative to initial prodrug concentration | Rattus norvegicus | 3 | assay format | Scientific Literature | ||
| 11. | ALA3537360 | A | Activity at human recombinant CYP1A2-mediated drug metabolism treated with 5 uM DB868 after 180 mins incubation by HPLC-UV chromatography | Homo sapiens | 2 | single protein format | Scientific Literature | ||
| 12. | ALA3537366 | A | Drug metabolism in rat recombinant CYP1A2 treated with at 5 uM DB868 after 180 mins incubation by HPLC-UV chromatography | Rattus norvegicus | 2 | assay format | Scientific Literature | ||
| 13. | ALA3536461 | A | Drug metabolism in sandwich-cultured human hepatocytes treated with 10 uM DB868 after 4 hrs of incubation by HPLC-MS/MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 14. | ALA3536462 | A | Drug metabolism in sandwich-cultured rat hepatocytes treated with 10 uM DB868 after 4 hrs of incubation by HPLC-MS/MS analysis | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 15. | ALA3536463 | A | Drug metabolism in sandwich-cultured human hepatocytes treated with 10 uM DB868 after 24 hrs of incubation by HPLC-MS/MS analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 16. | ALA3536464 | A | Drug metabolism in sandwich-cultured rat hepatocytes treated with 10 uM DB868 after 24 hrs of incubation by HPLC-MS/MS analysis | Rattus norvegicus | 3 | cell-based format | Scientific Literature | ||
| 17. | ALA3536863 | A | Prodrug conversion in rat liver microsomes assessed as elution time treated with 10 uM DB868 after 180 mins incubation by HPLC-UV chromatography | Rattus norvegicus | 4 | assay format | Scientific Literature |
The page will load shortly, Thanks for your patience!