| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4479234 | B | Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay | Homo sapiens | 8 | cell-based format | Scientific Literature | ||
| 2. | ALA4479235 | B | Agonist activity at human oxytocin receptor high affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 3. | ALA4479236 | B | Agonist activity at human oxytocin receptor low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 4. | ALA4479237 | B | Displacement of [125I]-OVTA from human oxytocin receptor expressed in COS7 cell membrane | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 5. | ALA4479238 | B | Agonist activity at human oxytocin receptor C47A mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 6. | ALA4479239 | B | Ratio of EC50 for human oxytocin receptor high affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein to Ki for human oxytocin receptor high affinity site expressed in COS7 cell membrane | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 7. | ALA4479240 | B | Ratio of EC50 for human oxytocin receptor low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein to Ki for human oxytocin receptor low affinity site expressed in COS7 cell membrane | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 8. | ALA4479243 | B | Agonist activity at human oxytocin receptor V43A/C47A double mutant expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins by Gq protein activation based BRET assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 9. | ALA4479246 | B | Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH1-TAT peptide by Gq protein activation based BRET assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 10. | ALA4479247 | B | Agonist activity at human oxytocin receptor expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH5-TAT peptide by Gq protein activation based BRET assay | Homo sapiens | 5 | cell-based format | Scientific Literature | ||
| 11. | ALA4479248 | F | Effect on social behavior in OXTR+/- DBA/2J mouse assessed as increase in time spent exploring stranger mouse over time spent exploring empty cage at 0.005 ng/mouse, icv measured for 10 mins by three chamber method | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 12. | ALA4479250 | F | Potency index, ratio of oxytocin dose to compound dose for OXTR+/- DBA/2J mouse assessed as increase in time spent exploring stranger mouse over time spent exploring empty cage | Mus musculus | 1 | organism-based format | Scientific Literature | ||
| 13. | ALA4479251 | F | Effect on social behavior in zebra fish assessed as increase in time spent swimming parallel to nacre mutant fish over time spent shoaling close to wild type fish at 0.2 ng/kg, im | Danio rerio | 1 | organism-based format | Scientific Literature | ||
| 14. | ALA4479253 | F | Potency index, ratio of isotocin dose to compound dose for effect on shoaling behavior in zebra fish | Danio rerio | 1 | organism-based format | Scientific Literature | ||
| 15. | ALA4479254 | B | Agonist activity at human oxytocin receptor high affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH5-TAT peptide by Gq protein activation based BRET assay | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 16. | ALA4479255 | B | Agonist activity at human oxytocin receptor low affinity site expressed in HEK293 cells coexpressing Rluc8-tagged Galphaq, N-terminal GFP-tagged Ggamma2 and Gbeta1 protein incubated for 2 mins in presence of TMH5-TAT peptide by Gq protein activation based BRET assay | Homo sapiens | 2 | cell-based format | Scientific Literature |
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