# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4376103 | Binding | Inhibition of recombinant human N-terminal His6-tagged glutaminyl cyclase (Ala33 to Leu361 residues) expressed in baculovirus infected Sf21 insect cells using H-Gln-AMC hydrobromide as substrate measured in presence of pGAPase by fluorometric assay | Homo sapiens | 68 | ALA4373720 | cell-based format | Scientific Literature | |
2. | ALA4376104 | ADME | Cytotoxicity against mouse HT22 cells assessed as cell viability at 10 uM measured after 18 hrs by MTT assay relative to control | Mus musculus | 24 | ALA4373720 | cell-based format | Scientific Literature | |
3. | ALA4376105 | Binding | Displacement of tracer red from human ERG at 10 uM by fluorescence polarization assay relative to control | Homo sapiens | 23 | ALA4373720 | single protein format | Scientific Literature | |
4. | ALA4376106 | Functional | Neuroprotection in human amyloid beta (3 to 40 residues)-induced ICR mouse model of Alzheimer's disease assessed as inhibition of human amyloid beta N3pE-40 level in brain at 25 mg/kg, icv measured after 24 hrs by sandwich ELISA relative to control | Mus musculus | 24 | ALA4373720 | organism-based format | Scientific Literature |