# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4376727 | Binding | Inhibition of recombinant full length human HDAC3 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 3 hrs by electrophoretic mobility shift assay | Homo sapiens | 12 | ALA4373747 | cell-based format | Scientific Literature | |
2. | ALA4376728 | Binding | Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells using FAM-RHKK-Ac as substrate incubated for 5 hrs by electrophoretic mobility shift assay | Homo sapiens | 12 | ALA4373747 | cell-based format | Scientific Literature | |
3. | ALA4376729 | Binding | Inhibition of recombinant full length human HDAC8 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 3 hrs by electrophoretic mobility shift assay | Homo sapiens | 12 | ALA4373747 | cell-based format | Scientific Literature | |
4. | ALA4376730 | Binding | Inhibition of recombinant full length human HDAC11 expressed in baculovirus infected Sf9 cells using FAM-RHKK-TFAc as substrate incubated for 17 hrs by electrophoretic mobility shift assay | Homo sapiens | 12 | ALA4373747 | cell-based format | Scientific Literature | |
5. | ALA4376731 | Binding | Inhibition of recombinant full length human HDAC6 expressed in baculovirus infected Sf9 cells assessed as inhibitory constant using FAM-RHKK-Ac as substrate incubated for 5 hrs by electrophoretic mobility shift assay | Homo sapiens | 12 | ALA4373747 | cell-based format | Scientific Literature | |
6. | ALA4376732 | Functional | Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer blue assay | Homo sapiens | 12 | ALA4373747 | cell-based format | Scientific Literature | |
7. | ALA4376733 | Functional | Cytotoxicity against human MOLM13 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer blue assay | Homo sapiens | 12 | ALA4373747 | cell-based format | Scientific Literature | |
8. | ALA4376734 | Functional | Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer blue assay | Homo sapiens | 8 | ALA4373747 | cell-based format | Scientific Literature | |
9. | ALA4376735 | Functional | Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer blue assay | Homo sapiens | 9 | ALA4373747 | cell-based format | Scientific Literature | |
10. | ALA4376736 | ADME | Cytotoxicity against human MRC9 cells assessed as reduction in cell viability incubated for 72 hrs by cell-titer blue assay | Homo sapiens | 9 | ALA4373747 | cell-based format | Scientific Literature | |
11. | ALA4376761 | ADME | Intrinsic clearance in ICR/CD1 mouse hepatocytes at 1 uM measured upto 120 mins by LCMS analysis | Mus musculus | 3 | ALA4373747 | cell-based format | Scientific Literature | |
12. | ALA4376762 | ADME | Protein binding in CD-1 mouse plasma at 1 uM incubated for 6 hrs by LCMS analysis | Mus musculus | 2 | ALA4373747 | cell-free format | Scientific Literature | |
13. | ALA4376763 | ADME | Stability in CD-1 mouse hepatocytes assessed as compound remaining at 1 uM measured up to 6 hrs by LCMS analysis | Mus musculus | 2 | ALA4373747 | cell-based format | Scientific Literature | |
14. | ALA4376764 | ADME | Permeability coefficient of compound at 10 uM incubated for 16 hrs by PAMPA based LCMS analysis | 2 | ALA4373747 | assay format | Scientific Literature | ||
15. | ALA4376765 | ADME | Apparent permeability from apical to basolateral side in human Caco2 cells incubated for 2 hrs by LC/MS analysis | Homo sapiens | 2 | ALA4373747 | cell-based format | Scientific Literature | |
16. | ALA4376766 | ADME | Efflux ratio of apparent permeability in human Caco2 cells incubated for 2 hrs by LC/MS analysis | Homo sapiens | 4 | ALA4373747 | cell-based format | Scientific Literature | |
17. | ALA4401642 | Binding | Inhibition of recombinant human HDAC3 expressed in SF9 baculoviral system using FAM-labeled acetylated peptide as substrate by EMSA | Homo sapiens | 8 | ALA4400543 | cell-based format | Scientific Literature | |
18. | ALA4401643 | Binding | Inhibition of recombinant human HDAC6 expressed in SF9 baculoviral system using FAM-labeled acetylated peptide as substrate by EMSA | Homo sapiens | 8 | ALA4400543 | cell-based format | Scientific Literature | |
19. | ALA4401644 | Binding | Inhibition of recombinant human HDAC8 expressed in SF9 baculoviral system using FAM-labeled acetylated peptide as substrate by EMSA | Homo sapiens | 8 | ALA4400543 | cell-based format | Scientific Literature | |
20. | ALA4401645 | Binding | Inhibition of recombinant human HDAC11 expressed in SF9 baculoviral system using FAM-labeled acetylated peptide as substrate by EMSA | Homo sapiens | 8 | ALA4400543 | cell-based format | Scientific Literature |