# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4343601 | Binding | Inhibition of human SGLT2 expressed i HEK293 cell membranes assessed as reduction in [14C]-alpha-methyl glucopyranoside uptake incubated for 4 hrs by topcount method | Homo sapiens | 1 | ALA4342422 | cell-based format | Scientific Literature | |
2. | ALA4343602 | Functional | Antidiabetic activity in human T2DM patients assessed as reduction in HbA1c level at 10 mg, po relative to control | Homo sapiens | 1 | ALA4342422 | organism-based format | Scientific Literature | |
3. | ALA4343603 | Functional | Antidiabetic activity in human T2DM patients assessed as reduction in HbA1c level at 25 mg, po relative to control | Homo sapiens | 1 | ALA4342422 | organism-based format | Scientific Literature | |
4. | ALA4343604 | Functional | Antidiabetic activity in human T2DM patients assessed as reduction in body weight at 10 to 25 mg, po | Homo sapiens | 1 | ALA4342422 | organism-based format | Scientific Literature | |
5. | ALA4343605 | Toxicity | Toxicity in human T2DM patients assessed as reduction in systolic blood pressure at 25 mg, po | Homo sapiens | 1 | ALA4342422 | assay format | Scientific Literature | |
6. | ALA4343606 | Toxicity | Toxicity in human T2DM patients assessed as reduction in diastolic blood pressure at 25 mg, po | Homo sapiens | 1 | ALA4342422 | assay format | Scientific Literature | |
7. | ALA4343607 | ADME | Half life in human | Homo sapiens | 1 | ALA4342422 | assay format | Scientific Literature | |
8. | ALA4343612 | Binding | Inhibition of human SGLT1 | Homo sapiens | 9 | ALA4342422 | single protein format | Scientific Literature | |
9. | ALA4343613 | Binding | Inhibition of human SGLT2 | Homo sapiens | 10 | ALA4342422 | single protein format | Scientific Literature | |
10. | ALA4343622 | Binding | Selectivity ratio of IC50 for inhibition of human SGLT1 to IC50 for inhibition of human SGLT2 | Homo sapiens | 9 | ALA4342422 | assay format | Scientific Literature |