| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4348241 | F | Induction of apoptosis in human U251 cells assessed as late apoptotic cells at 0.5 uM incubated for 48 hrs by annexin-V-FITC staining based cell counter assay (Rvb = 9.80%) | Homo sapiens | 8 | ALA4346681 | cell-based format | Scientific Literature | |
| 2. | ALA4348242 | F | Induction of apoptosis in human U251 cells assessed as early apoptotic cells at 0.5 uM incubated for 48 hrs by annexin-V-FITC staining based cell counter assay (Rvb = 0.70%) | Homo sapiens | 8 | ALA4346681 | cell-based format | Scientific Literature | |
| 3. | ALA4348243 | F | Induction of apoptosis in human U251 cells assessed as viable cells at 0.5 uM incubated for 48 hrs by annexin-V-FITC staining based cell counter assay (Rvb = 82.75 to 85.65%) | Homo sapiens | 8 | ALA4346681 | cell-based format | Scientific Literature | |
| 4. | ALA4348244 | F | Induction of apoptosis in human HCT116 cells expressing wild type p53 assessed as decrease in mitochondrial cytochrome c expression at 4 times antiproliferative IC50 incubated for 24 hrs by Western blot analysis relative to control | Homo sapiens | 8 | ALA4346681 | cell-based format | Scientific Literature | |
| 5. | ALA4348245 | F | Antiproliferative activity against human HCT116 cells expressing wild type p53 incubated for 72 hrs by MTS assay | Homo sapiens | 19 | ALA4346681 | cell-based format | Scientific Literature | |
| 6. | ALA4348246 | F | Antiproliferative activity against human HCT116 cells deficient in p53 incubated for 72 hrs by MTS assay | Homo sapiens | 19 | ALA4346681 | cell-based format | Scientific Literature | |
| 7. | ALA4348247 | F | Antiproliferative activity against human MCF7 cells incubated for 72 hrs by MTS assay | Homo sapiens | 16 | ALA4346681 | cell-based format | Scientific Literature | |
| 8. | ALA4348248 | F | Antiproliferative activity against human U251 cells incubated for 72 hrs by MTS assay | Homo sapiens | 16 | ALA4346681 | cell-based format | Scientific Literature | |
| 9. | ALA4348249 | F | Antiproliferative activity against human Hs683 cells incubated for 72 hrs by MTS assay | Homo sapiens | 16 | ALA4346681 | cell-based format | Scientific Literature | |
| 10. | ALA4348250 | A | Antiproliferative activity against human NHDF cells incubated for 72 hrs by MTS assay | Homo sapiens | 19 | ALA4346681 | cell-based format | Scientific Literature | |
| 11. | ALA4348251 | U | Selectivity index, ratio of IC50 for human NHDF cells to IC50 for human HCT116 cells expressing wild type p53 | Homo sapiens | 19 | ALA4346681 | assay format | Scientific Literature | |
| 12. | ALA4348252 | U | Selectivity index, ratio of IC50 for human NHDF cells to IC50 for human HCT116 cells deficient in p53 | Homo sapiens | 19 | ALA4346681 | assay format | Scientific Literature | |
| 13. | ALA4348253 | U | Selectivity index, ratio of IC50 for human NHDF cells to IC50 for human MCF7 cells | Homo sapiens | 16 | ALA4346681 | assay format | Scientific Literature | |
| 14. | ALA4348254 | U | Selectivity index, ratio of IC50 for human NHDF cells to IC50 for human U251 cells | Homo sapiens | 16 | ALA4346681 | assay format | Scientific Literature | |
| 15. | ALA4348255 | U | Selectivity index, ratio of IC50 for human NHDF cells to IC50 for human Hs683 cells | Homo sapiens | 16 | ALA4346681 | assay format | Scientific Literature | |
| 16. | ALA4348257 | F | Induction of cell cycle arrest in human HCT116 cells expressing wild type p53 assessed as cell accumulation at G0/G1 phase at 0.5 uM incubated for 48 hrs by cell counter based assay (Rvb = 48.78 to 48.8%) | Homo sapiens | 8 | ALA4346681 | cell-based format | Scientific Literature | |
| 17. | ALA4348258 | F | Induction of cell cycle arrest in human HCT116 cells expressing wild type p53 assessed as cell accumulation at S phase at 0.5 uM incubated for 48 hrs by cell counter based assay (Rvb = 11.7 to 13.15%) | Homo sapiens | 8 | ALA4346681 | cell-based format | Scientific Literature | |
| 18. | ALA4348259 | F | Induction of cell cycle arrest in human HCT116 cells expressing wild type p53 assessed as cell accumulation at G2/M phase at 0.5 uM incubated for 48 hrs by cell counter based assay (Rvb 30.63 to 32.4%) | Homo sapiens | 8 | ALA4346681 | cell-based format | Scientific Literature | |
| 19. | ALA4348260 | F | Induction of cell cycle arrest in human MCF7 cells assessed as cell accumulation at G0/G1 phase at 0.5 uM incubated for 48 hrs by cell counter based assay (Rvb = 50.1 to 51.48%) | Homo sapiens | 8 | ALA4346681 | cell-based format | Scientific Literature | |
| 20. | ALA4348261 | F | Induction of cell cycle arrest in human MCF7 cells assessed as cell accumulation at S phase at 0.5 uM incubated for 48 hrs by cell counter based assay (Rvb = 10.88 to 11.7%) | Homo sapiens | 8 | ALA4346681 | cell-based format | Scientific Literature |
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