# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4361879 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as induction of degradation of IRAK4 incubated for 24 hrs by Western blot analysis | Homo sapiens | 2 | protein format | Scientific Literature | ||
2. | ALA4361883 | P | Solubility of compound | 2 | small-molecule physicochemical format | Scientific Literature | |||
3. | ALA4361884 | A | Clearance in human liver microsomes | Homo sapiens | 2 | microsome format | Scientific Literature | ||
4. | ALA4361885 | A | Clearance in rat liver microsomes | Rattus norvegicus | 2 | microsome format | Scientific Literature | ||
5. | ALA4361886 | B | Protac activity at VHL/IRAK4 in human epoxomicin PBMC assessed as increase in p21 accumulation at 0.01 to 10 uM incubated for 22 hrs by Western blot analysis | Homo sapiens | 1 | protein format | Scientific Literature | ||
6. | ALA4361887 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as reduction in R848-stimulated IL-1beta level preincubated for 18 hrs followed by R848-stimulation and measured after 8 hrs by MSD assay | Homo sapiens | 2 | protein format | Scientific Literature | ||
7. | ALA4361888 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as reduction in R848-stimulated IFNgamma preincubated for 18 hrs followed by R848 stimulation and measured after 8 hrs by MSD assay | Homo sapiens | 2 | protein format | Scientific Literature | ||
8. | ALA4361889 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as reduction in R848-stimulated IL-6 level preincubated for 18 hrs followed by R848 stimulation and measured after 8 hrs by MSD assay | Homo sapiens | 2 | protein format | Scientific Literature | ||
9. | ALA4361890 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as reduction in R848-stimulated IL-8 level preincubated for 18 hrs followed by R848 stimulation and measured after 8 hrs by MSD assay | Homo sapiens | 2 | protein format | Scientific Literature | ||
10. | ALA4361891 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as reduction in R848-stimulated IL-10 level preincubated for 18 hrs followed by R848 stimulation and measured after 8 hrs by MSD assay | Homo sapiens | 2 | protein format | Scientific Literature | ||
11. | ALA4361892 | B | Protac activity at VHL/IRAK4 in human PBMC assessed as reduction in R848-stimulated TNFalpha level preincubated for 18 hrs followed by R848 stimulation and measured after 8 hrs by MSD assay | Homo sapiens | 2 | protein format | Scientific Literature | ||
12. | ALA4361893 | B | Protac activity at VHL/IRAK4 in human dermal fibroblast assessed as induction of degradation of IRAK4 incubated for 24 hrs by Western blot analysis | Homo sapiens | 1 | protein format | Scientific Literature | ||
13. | ALA4361894 | B | Protac activity at VHL/IRAK4 in human dermal fibroblast assessed as reduction in IL-1beta stimulated IL-6 level at 300 nM incubated for 18 hrs followed by IL-1beta stimulation further incubated for 8 hrs by MSD assay | Homo sapiens | 2 | protein format | Scientific Literature | ||
14. | ALA4361898 | P | Chromatographic hydrophobicity index, log D of compound at pH 7.4 | 9 | small-molecule physicochemical format | Scientific Literature | |||
15. | ALA4361904 | B | Protac activity at VHL/IRAK4 in human epoxomicin pretreated PBMC assessed as induction of degradation of IRAK4 at 0.01 to 10 uM incubated for 22 hrs by Western blot analysis | Homo sapiens | 1 | protein format | Scientific Literature |