| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4432180 | Binding | Inhibition of S-COMT in Wistar rat liver assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate and SAM measured after 5 mins by chromatographic analysis | Rattus norvegicus | 16 | ALA4431327 | tissue-based format | Scientific Literature | |
| 2. | ALA4432181 | Binding | Inhibition of MB-COMT in Wistar rat brain assessed as metanephrine formation preincubated for 20 mins followed by addition of adrenaline as substrate and SAM measured after 15 mins by chromatographic analysis | Rattus norvegicus | 16 | ALA4431327 | tissue-based format | Scientific Literature | |
| 3. | ALA4432182 | Binding | Selectivity ratio, ratio of IC50 for S-COMT in Wistar rat liver to IC50 for MB-COMT in Wistar rat brain | Rattus norvegicus | 14 | ALA4431327 | assay format | Scientific Literature | |
| 4. | ALA4432183 | ADME | Permeability of the compound in PBS:EtOH (70:30) measured after 2 hrs and 30 mins by PAMPA-BBB assay | 15 | ALA4431327 | assay format | Scientific Literature |
The page will load shortly, Thanks for your patience!