# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4326986 | Binding | Binding affinity to human full-length JNK1 (M1 to Q384 residues) expressed in HEK293 cells at <40 uM after 1 hr by Kinomescan method | Homo sapiens | 7 | ALA4325855 | cell-based format | Scientific Literature | |
2. | ALA4326987 | Binding | Binding affinity to human full-length JNK2 (M1 to Q382 residues) expressed in HEK293 cells at <40 uM after 1 hr by Kinomescan method | Homo sapiens | 8 | ALA4325855 | cell-based format | Scientific Literature | |
3. | ALA4326988 | Binding | Binding affinity to human partial length JNK3 (V28 to Q422 residues) expressed in HEK293 cells at <40 uM after 1 hr by Kinomescan method | Homo sapiens | 8 | ALA4325855 | cell-based format | Scientific Literature | |
4. | ALA4326998 | Binding | Inhibition of JNK in human THP1-Blue cells assessed as reduction in LPS-induced NFkappaB/AP1 activation at <40 uM preincubated for 30 mins followed by LPS-stimulation and measured after 24 hrs by quanti-blue staining based alkaline phosphatase reporter gene assay | Homo sapiens | 9 | ALA4325855 | cell-based format | Scientific Literature | |
5. | ALA4327000 | Binding | Inhibition of JNK in human MONO-MAC-6 cells assessed as reduction in LPS-induced IL6 production at <40 uM preincubated for 30 mins followed by LPS-stimulation and measured after 24 hrs by ELISA | Homo sapiens | 9 | ALA4325855 | cell-based format | Scientific Literature | |
6. | ALA4327003 | ADME | Cytotoxicity against human THP1-Blue cells assessed as effect on cell viability up to 50 uM after 24 hrs by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 31 | ALA4325855 | cell-based format | Scientific Literature | |
7. | ALA4327004 | ADME | Cytotoxicity against human MONO-MAC-6 cells assessed as effect on cell viability up to 50 uM after 24 hrs by CellTiter-Glo luminescent cell viability assay | Homo sapiens | 31 | ALA4325855 | cell-based format | Scientific Literature |