# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4396706 | B | Agonist activity at PPARalpha in human Huh7 cells assessed as PPARA mRNA expression at 50 uM measured after 18 hrs by qRT-PCR analysis | Homo sapiens | 4 | ALA4393735 | cell-based format | Scientific Literature | |
2. | ALA4396708 | B | Agonist activity at PPARalpha in human Huh7 cells assessed as SCD1 mRNA expression at 50 uM measured after 18 hrs by qRT-PCR analysis | Homo sapiens | 4 | ALA4393735 | cell-based format | Scientific Literature | |
3. | ALA4396709 | B | Agonist activity at PPARalpha in human Huh7 cells assessed as SREBF1 mRNA expression at 50 uM measured after 18 hrs by qRT-PCR analysis | Homo sapiens | 4 | ALA4393735 | cell-based format | Scientific Literature | |
4. | ALA4396711 | B | Agonist activity at PPARalpha in C57BL/6N mouse primary hepatocytes assessed as PPARA mRNA expression at 50 uM measured after 18 hrs by qRT-PCR analysis | Mus musculus | 2 | ALA4393735 | cell-based format | Scientific Literature | |
5. | ALA4396712 | B | Agonist activity at PPARalpha in C57BL/6N mouse primary hepatocytes assessed as SCD1 mRNA expression at 50 uM measured after 18 hrs by qRT-PCR analysis | Mus musculus | 4 | ALA4393735 | cell-based format | Scientific Literature | |
6. | ALA4396713 | B | Agonist activity at PPARalpha in C57BL/6N mouse primary hepatocytes assessed as SREBF1 mRNA expression at 50 uM measured after 18 hrs by qRT-PCR analysis | Mus musculus | 4 | ALA4393735 | cell-based format | Scientific Literature | |
7. | ALA4396722 | F | Upregulation of PPARgamma gene expression in human preadipocyte derived from Simpson-Golabi-Behmel syndrome (SGBS) patient at 25 uM measured for 12 days by qRT-PCR analysis | Homo sapiens | 4 | ALA4393735 | cell-based format | Scientific Literature | |
8. | ALA4396724 | F | Upregulation of CEBPA gene expression in human preadipocyte derived from Simpson-Golabi-Behmel syndrome (SGBS) patient at 25 uM measured for 12 days by qRT-PCR analysis | Homo sapiens | 4 | ALA4393735 | cell-based format | Scientific Literature | |
9. | ALA4396726 | F | Upregulation of ACSL1 gene expression in human preadipocyte derived from Simpson-Golabi-Behmel syndrome (SGBS) patient at 25 uM measured for 12 days by qRT-PCR analysis | Homo sapiens | 4 | ALA4393735 | cell-based format | Scientific Literature | |
10. | ALA4396728 | F | Upregulation of CD36 gene expression in human preadipocyte derived from Simpson-Golabi-Behmel syndrome (SGBS) patient at 25 uM measured for 12 days by qRT-PCR analysis | Homo sapiens | 4 | ALA4393735 | cell-based format | Scientific Literature | |
11. | ALA4396730 | F | Upregulation of FABP4 gene expression in human preadipocyte derived from Simpson-Golabi-Behmel syndrome (SGBS) patient at 25 uM measured for 12 days by qRT-PCR analysis | Homo sapiens | 4 | ALA4393735 | cell-based format | Scientific Literature | |
12. | ALA4396732 | F | Upregulation of PLIN1 gene expression in human preadipocyte derived from Simpson-Golabi-Behmel syndrome (SGBS) patient at 25 uM measured for 12 days by qRT-PCR analysis | Homo sapiens | 4 | ALA4393735 | cell-based format | Scientific Literature | |
13. | ALA4396734 | F | Upregulation of ADIPOQ gene expression in human preadipocyte derived from Simpson-Golabi-Behmel syndrome (SGBS) patient at 25 uM measured for 12 days by qRT-PCR analysis | Homo sapiens | 4 | ALA4393735 | cell-based format | Scientific Literature | |
14. | ALA4396736 | F | Upregulation of ANGPTL4 gene expression in human preadipocyte derived from Simpson-Golabi-Behmel syndrome (SGBS) patient at 25 uM measured for 12 days by qRT-PCR analysis | Homo sapiens | 4 | ALA4393735 | cell-based format | Scientific Literature | |
15. | ALA4396738 | F | Induction of adipocyte differentiation in human preadipocyte derived from Simpson-Golabi-Behmel syndrome (SGBS) patient assessed as lipid accumulation at 25 uM measured for 12 days by Oil red O staining based microscopic analysis | Homo sapiens | 4 | ALA4393735 | cell-based format | Scientific Literature | |
16. | ALA4721820 | B | Agonist activity at recombinant human PPARalpha LBD (168 to 468 residues) expressed in African green monkey COS-1 cells incubated for 18 hrs by luciferase reporter gene assay | Homo sapiens | 4 | ALA4715825 | cell-based format | Scientific Literature | |
17. | ALA4721821 | B | Agonist activity at recombinant human PPARgamma LBD (205 to 505 residues) expressed in African green monkey COS-1 cells incubated for 18 hrs by luciferase reporter gene assay | Homo sapiens | 3 | ALA4715825 | cell-based format | Scientific Literature | |
18. | ALA4721822 | A | Cytotoxicity against African green monkey COS-1 cells assessed as cell viability at EC50 concentration for PPAR activation assay by LDH assay | Chlorocebus aethiops | 5 | ALA4715825 | cell-based format | Scientific Literature | |
19. | ALA4721823 | A | Cytotoxicity against African green monkey COS-1 cells assessed as cell viability at EC50 concentration for PPAR activation assay by XTT assay | Chlorocebus aethiops | 5 | ALA4715825 | cell-based format | Scientific Literature | |
20. | ALA4721824 | B | Agonist activity at recombinant human PPARalpha LBD (168 to 468 residues) expressed in African green monkey COS-1 cells at 25 to 50 uM incubated for 18 hrs by luciferase reporter gene assay | Homo sapiens | 2 | ALA4715825 | cell-based format | Scientific Literature |