# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4398131 | B | Protac activity at Cereblon/MCL1 in human OPM2 cells assessed as protein abundance at 500 nM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4396889 | cell-based format | Scientific Literature | |
2. | ALA4398132 | B | Protac activity at Cereblon/MCL1 in human OPM2 cells assessed as protein abundance at 250 nM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4396889 | cell-based format | Scientific Literature | |
3. | ALA4398133 | B | Protac activity at Cereblon/MCL1 in human OPM2 cells assessed as protein abundance at 100 nM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4396889 | cell-based format | Scientific Literature | |
4. | ALA4398134 | B | Protac activity at Cereblon/MCL1 in human OPM2 cells assessed as protein abundance at 25 nM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4396889 | cell-based format | Scientific Literature | |
5. | ALA4398136 | B | Protac activity at Cereblon/MCL1 in human OPM2 cell lysate assessed as induction of MCL1 polyubiquitination incubated for 3 hrs by SDS-PAGE/immunoblot analysis | Homo sapiens | 2 | ALA4396889 | subcellular format | Scientific Literature | |
6. | ALA4398137 | B | Protac activity at N-terminal His-tagged human MCL1 expressed in Escherichia coli/Cereblon in human OPM2 cell lysate assessed as ternary complex formation at 500 nM incubated for 1 hr followed by cell lysate addition after overnight incubation by SDS-PAGE/immunoblot analysis | Homo sapiens | 1 | ALA4396889 | assay format | Scientific Literature | |
7. | ALA4398141 | B | Binding affinity to His-tagged biotinylated human MCL1 by surface plasmon resonance method | Homo sapiens | 2 | ALA4396889 | single protein format | Scientific Literature | |
8. | ALA4398142 | B | Protac activity at Cereblon/MCL1 in human OPM2 cells assessed as protein abundance at 1 uM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 1 | ALA4396889 | cell-based format | Scientific Literature | |
9. | ALA4398144 | B | Protac activity at Cereblon/MCL1 in human OPM2 cells at 500 nM after 3 hrs in presence of proteasome inhibitor bortezomib by immunoblot analysis | Homo sapiens | 1 | ALA4396889 | cell-based format | Scientific Literature | |
10. | ALA4398145 | B | Protac activity at Cereblon/MCL1 long isoform in wild type human OPM2 cells assessed as protein abundance at 50 nM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 2 | ALA4396889 | cell-based format | Scientific Literature | |
11. | ALA4398146 | B | Protac activity at Cereblon/MCL1 long isoform in wild type human OPM2 cells at 100 nM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 2 | ALA4396889 | cell-based format | Scientific Literature | |
12. | ALA4398147 | B | Protac activity at Cereblon/MCL1 long isoform in wild type human OPM2 cells at 250 nM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 2 | ALA4396889 | cell-based format | Scientific Literature | |
13. | ALA4398148 | B | Protac activity at Cereblon/MCL1 long isoform in wild type human OPM2 cells at 500 nM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 2 | ALA4396889 | cell-based format | Scientific Literature | |
14. | ALA4398149 | B | Protac activity at Cereblon/MCL1 short isoform in wild type human OPM2 cells assessed as MCL1 short isoform abundance at 50 nM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 2 | ALA4396889 | cell-based format | Scientific Literature | |
15. | ALA4398150 | B | Protac activity at Cereblon/MCL1 short isoform in wild type human OPM2 cells assessed as MCL1 short isoform abundance at 100 nM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 2 | ALA4396889 | cell-based format | Scientific Literature | |
16. | ALA4398151 | B | Protac activity at Cereblon/MCL1 short isoform in wild type human OPM2 cells assessed as MCL1 short isoform abundance at 250 nM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 2 | ALA4396889 | cell-based format | Scientific Literature | |
17. | ALA4398152 | B | Protac activity at Cereblon/MCL1 short isoform in wild type human OPM2 cells assessed as MCL1 short isoform abundance at 500 nM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 2 | ALA4396889 | cell-based format | Scientific Literature | |
18. | ALA4398153 | B | Induction of MCL1 long isoform degradation in CRBN-/- human OPM2 cells assessed as protein abundance at 50 nM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 2 | ALA4396889 | cell-based format | Scientific Literature | |
19. | ALA4398154 | B | Induction of MCL1 long isoform degradation in CRBN-/- human OPM2 cells assessed as protein abundance at 100 nM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 2 | ALA4396889 | cell-based format | Scientific Literature | |
20. | ALA4398155 | B | Induction of MCL1 long isoform degradation in CRBN-/- human OPM2 cells assessed as protein abundance at 250 nM after 48 hrs by immunoblot analysis relative to control | Homo sapiens | 2 | ALA4396889 | cell-based format | Scientific Literature |