# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4402085 | Functional | Agonist activity at human RXFP3 expressed in CHOK1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation preincubated for 30 mins followed by forskolin-stimulation and measured after 30 mins by HTRF assay | Homo sapiens | 4 | ALA4400563 | cell-based format | Scientific Literature | |
2. | ALA4402086 | Functional | Agonist activity at human RXFP3 expressed in CHOK1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation preincubated for 30 mins followed by forskolin-stimulation and measured after 30 mins by HTRF assay relative to relaxin-3 | Homo sapiens | 4 | ALA4400563 | cell-based format | Scientific Literature | |
3. | ALA4402088 | Functional | Agonist activity at human RXFP4 expressed in CHOK1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation preincubated for 30 mins followed by forskolin-stimulation and measured after 30 mins by HTRF assay | Homo sapiens | 4 | ALA4400563 | cell-based format | Scientific Literature | |
4. | ALA4402089 | Functional | Agonist activity at human RXFP4 expressed in CHOK1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation preincubated for 30 mins followed by forskolin-stimulation and measured after 30 mins by HTRF assay relative to relaxin-3 | Homo sapiens | 4 | ALA4400563 | cell-based format | Scientific Literature | |
5. | ALA4402090 | Functional | Agonist activity at human RXFP3 expressed in CHOK1 cell membranes assessed as stimulation of [35S]-GTPgammaS binding after 3 hrs by scintillation counting method | Homo sapiens | 1 | ALA4400563 | cell-based format | Scientific Literature | |
6. | ALA4402091 | Functional | Agonist activity at human RXFP4 expressed in CHOK1 cell membranes assessed as stimulation of [35S]-GTPgammaS binding after 3 hrs by scintillation counting method | Homo sapiens | 1 | ALA4400563 | cell-based format | Scientific Literature | |
7. | ALA4402092 | Binding | Agonist activity at human RXFP3/4 in human U2OS cells assessed as induction of beta-arrestin recruitment incubated for 1 hr by chemiluminescence based PathHunter beta-arrestin assay | Homo sapiens | 1 | ALA4400563 | cell-based format | Scientific Literature | |
8. | ALA4402093 | Binding | Agonist activity at human RXFP3 expressed in CHOK1 cells assessed as induction of ERK1/2 phosphorylation at 5 uM by Western blot analysis | Homo sapiens | 1 | ALA4400563 | cell-based format | Scientific Literature | |
9. | ALA4402094 | Binding | Agonist activity at human RXFP3 expressed in CHOK1 cells assessed as induction of JNK phosphorylation at 5 uM by Western blot analysis | Homo sapiens | 1 | ALA4400563 | cell-based format | Scientific Literature | |
10. | ALA4402095 | Binding | Agonist activity at human RXFP3 expressed in CHOK1 cells assessed as induction of p38 MAPK phosphorylation at 5 uM by Western blot analysis | Homo sapiens | 1 | ALA4400563 | cell-based format | Scientific Literature | |
11. | ALA4402096 | Functional | Induction of food intake in satiated Sprague-Dawley rat at 1 umol, icv after 0 to 2 hrs (Rvb = 1.7 +/- 0.5g) | Rattus norvegicus | 1 | ALA4400563 | organism-based format | Scientific Literature | |
12. | ALA4402097 | Functional | Induction of food intake in Sprague-Dawley rat at 1 umol, icv after 4 hrs (Rvb = 2.5 +/- 0.6g) | Rattus norvegicus | 1 | ALA4400563 | organism-based format | Scientific Literature | |
13. | ALA4402098 | Functional | Induction of food intake in Sprague-Dawley rat at 1 umol, icv after 24 hrs (Rvb = 24.1 +/- 2.7g) | Rattus norvegicus | 1 | ALA4400563 | organism-based format | Scientific Literature | |
14. | ALA4402099 | Binding | Agonist activity at human RXFP3/4 in human U2OS cells assessed as induction of beta-arrestin recruitment incubated for 1 hr by chemiluminescence based PathHunter beta-arrestin assay relative to relaxin-3 | Homo sapiens | 1 | ALA4400563 | cell-based format | Scientific Literature | |
15. | ALA4402100 | Binding | Induction of ERK1/2 phosphorylation CHOK1 cells at 5 uM by Western blot analysis | Cricetulus griseus | 1 | ALA4400563 | assay format | Scientific Literature | |
16. | ALA4402101 | Binding | Induction of p38 MAPK phosphorylation CHOK1 cells at 5 uM by Western blot analysis | Cricetulus griseus | 1 | ALA4400563 | assay format | Scientific Literature | |
17. | ALA4402102 | Binding | Induction of JNK phosphorylation CHOK1 cells at 5 uM by Western blot analysis | Cricetulus griseus | 1 | ALA4400563 | assay format | Scientific Literature | |
18. | ALA4402103 | ADME | Effect on total ERK1/2 protein levels in CHOK1 cells at 5 uM by Western blot analysis | Cricetulus griseus | 1 | ALA4400563 | cell-based format | Scientific Literature | |
19. | ALA4402104 | ADME | Effect on total JNK protein levels in CHOK1 cells at 5 uM by Western blot analysis | Cricetulus griseus | 1 | ALA4400563 | cell-based format | Scientific Literature | |
20. | ALA4402105 | ADME | Effect on total p38 MAPK protein levels in CHOK1 cells at 5 uM by Western blot analysis | Cricetulus griseus | 1 | ALA4400563 | cell-based format | Scientific Literature |