| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4425980 | P | Aqueous solubility of the compound measured after 4 hrs by HPLC method | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 2. | ALA4425981 | B | Competitive inhibition of [14C]-L-leucine uptake at LAT1 in human MCF7 cells preincubated for 5 mins followed by addition of substrate measured during 5 mins by liquid scintillation counting | Homo sapiens | 2 | cell-based format | Scientific Literature | ||
| 3. | ALA4425983 | B | Competitive inhibition of [14C]-L-leucine uptake at LAT1 in human MCF7 cells at 25 uM preincubated for 10 mins followed by addition of substrate measured during 5 mins by liquid scintillation counting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 4. | ALA4425984 | B | Competitive inhibition of [14C]-L-alanine uptake at LAT2 in human MCF7 cells at 25 uM preincubated for 5 mins followed by addition of substrate measured during 5 mins by liquid scintillation counting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 5. | ALA4425985 | B | Competitive inhibition of [14C]-L-alanine uptake at LAT2 in human MCF7 cells at 100 uM preincubated for 10 mins followed by addition of substrate measured during 5 mins by liquid scintillation counting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 6. | ALA4425986 | B | Competitive inhibition of [14C]-L-leucine uptake at LAT1 in human MCF7 cells at 100 uM preincubated for 10 mins followed by addition of substrate measured during 5 mins by liquid scintillation counting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 7. | ALA4425987 | B | Competitive inhibition of [14C]-L-alanine uptake at LAT2 in human MCF7 cells at 50 to 1000 uM measured during 5 mins by liquid scintillation counting | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 8. | ALA4425988 | A | Drug uptake in human MCF7 cells assessed as LAT1 mediated drug transport per mg of protein at 100 uM measured 5 mins after cold wash by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 9. | ALA4425989 | A | Drug uptake in human MCF7 cells assessed as LAT1 mediated drug transport per mg of protein at 100 uM measured 30 mins after cold wash by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 10. | ALA4425990 | A | Drug uptake in human MCF7 cells assessed as LAT1 mediated drug transport per mg of protein at 100 uM measured 5 mins after warm wash by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 11. | ALA4425991 | A | Drug uptake in human MCF7 cells assessed as LAT1 mediated drug transport per mg of protein at 100 uM measured 30 mins after warm wash by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 12. | ALA4425992 | B | Competitive binding to LAT1 in human MCF7 cells at 100 uM after 30 mins in presence of MCT1 inhibitor phloretin by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 13. | ALA4425993 | B | Competitive binding to LAT1 in human MCF7 cells at 100 uM after 30 mins in presence of OATP 1A2/2B1 inhibitor naringin by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 14. | ALA4425994 | B | Competitive binding to LAT1 in human MCF7 cells at 100 uM after 30 mins in presence of OATP 1B1/1B3 inhibitor rifampicin by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 15. | ALA4425995 | B | Competitive binding to LAT1 in human MCF7 cells at 100 uM after 30 mins in presence of unselective OATP substrate L-thyroxine by HPLC analysis | Homo sapiens | 1 | cell-based format | Scientific Literature | ||
| 16. | ALA4425996 | P | Chemical stability of the compound in Tris-HCl buffer at pH 7.4 and 37 degreeC measured after 24 hrs by HPLC method | 1 | small-molecule physicochemical format | Scientific Literature | |||
| 17. | ALA4425997 | A | Metabolic stability in mouse liver S9 fraction at 37 degreeC in presence of NADPH regenerating system measured after 2 hrs by HPLC analysis | Mus musculus | 1 | subcellular format | Scientific Literature | ||
| 18. | ALA4425998 | A | Metabolic stability in human plasma at 37 degreeC in presence of NADPH regenerating system measured after 2 hrs by HPLC analysis | Homo sapiens | 1 | cell-free format | Scientific Literature | ||
| 19. | ALA4425999 | F | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability measured after 72 hrs by resazurin dye-based fluorimetric analysis | Homo sapiens | 3 | cell-based format | Scientific Literature | ||
| 20. | ALA4426000 | F | Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability at 25 uM measured after 24 hrs by resazurin dye-based fluorimetric analysis | Homo sapiens | 1 | cell-based format | Scientific Literature |
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