# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4369450 | Functional | Cytotoxicity against human K562 cells assessed as inhibition of cell growth after 72 hrs by MTT assay | Homo sapiens | 11 | ALA4368873 | cell-based format | Scientific Literature | |
2. | ALA4369451 | Functional | Cytotoxicity against human HL60 cells assessed as inhibition of cell growth after 72 hrs by MTT assay | Homo sapiens | 11 | ALA4368873 | cell-based format | Scientific Literature | |
3. | ALA4369452 | Functional | Cytotoxicity against human Jurkat cells assessed as inhibition of cell growth after 72 hrs by MTT assay | Homo sapiens | 11 | ALA4368873 | cell-based format | Scientific Literature | |
4. | ALA4369453 | Functional | Cytotoxicity against human Raji cells assessed as inhibition of cell growth after 72 hrs by MTT assay | Homo sapiens | 11 | ALA4368873 | cell-based format | Scientific Literature | |
5. | ALA4369454 | Functional | Cytotoxicity against human MCF7 cells assessed as inhibition of cell growth after 72 hrs by MTT assay | Homo sapiens | 11 | ALA4368873 | cell-based format | Scientific Literature | |
6. | ALA4369455 | Functional | Cytotoxicity against human MDA-MB-231 cells assessed as inhibition of cell growth after 72 hrs by MTT assay | Homo sapiens | 11 | ALA4368873 | cell-based format | Scientific Literature | |
7. | ALA4369456 | Functional | Cytotoxicity against human HeLa cells assessed as inhibition of cell growth after 72 hrs by MTT assay | Homo sapiens | 11 | ALA4368873 | cell-based format | Scientific Literature | |
8. | ALA4369457 | Functional | Cytotoxicity against human A549 cells assessed as inhibition of cell growth after 72 hrs by MTT assay | Homo sapiens | 11 | ALA4368873 | cell-based format | Scientific Literature | |
9. | ALA4369458 | ADME | Cytotoxicity against human MRC5 cells assessed as inhibition of cell growth after 72 hrs by MTT assay | Homo sapiens | 11 | ALA4368873 | cell-based format | Scientific Literature | |
10. | ALA4369461 | Functional | Cell cycle arrest in human K562 cells assessed as accumulation at sub-G1 phase at IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 1.84%) | Homo sapiens | 10 | ALA4368873 | cell-based format | Scientific Literature | |
11. | ALA4369462 | Functional | Cell cycle arrest in human K562 cells assessed as accumulation at G0/G1 phase at IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 47.51%) | Homo sapiens | 10 | ALA4368873 | cell-based format | Scientific Literature | |
12. | ALA4369463 | Functional | Cell cycle arrest in human K562 cells assessed as accumulation at S phase at IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 26.52%) | Homo sapiens | 10 | ALA4368873 | cell-based format | Scientific Literature | |
13. | ALA4369464 | Functional | Cell cycle arrest in human K562 cells assessed as accumulation at G2/M phase at IC50 after 72 hrs by propidium iodide staining based flow cytometry (Rvb = 24.13%) | Homo sapiens | 10 | ALA4368873 | cell-based format | Scientific Literature | |
14. | ALA4369466 | Functional | Induction of apoptosis in human K562 cells assessed as apoptotic cells at IC50 after 72 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control | Homo sapiens | 10 | ALA4368873 | cell-based format | Scientific Literature | |
15. | ALA4369467 | Functional | Induction of apoptosis in human K562 cells assessed as necrotic cells at IC50 after 72 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry relative to control | Homo sapiens | 10 | ALA4368873 | cell-based format | Scientific Literature | |
16. | ALA4369469 | Functional | Down regulation of Bcl-2 expression in human K562 cells at IC50 measured after 72 hrs by Western blot analysis | Homo sapiens | 4 | ALA4368873 | cell-based format | Scientific Literature | |
17. | ALA4369470 | Functional | Up regulation of Bax expression in human K562 cells at IC50 measured after 72 hrs by Western blot analysis | Homo sapiens | 6 | ALA4368873 | cell-based format | Scientific Literature | |
18. | ALA4369474 | Functional | Up regulation of cleaved PARP expression in human K562 cells at IC50 measured after 72 hrs by Western blot analysis | Homo sapiens | 10 | ALA4368873 | cell-based format | Scientific Literature |