# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4307491 | Binding | Inhibition of human TRPV4 expressed in baculovirus infected HEK/MSR 2 cells pre-incubated for 10 mins followed by GSK634775A addition by Fura-2 dye based FLIPR assay | Homo sapiens | 30 | ALA4304797 | cell-based format | Scientific Literature | |
2. | ALA4307493 | ADME | Mean residence time in Sprague-Dawley rat at 1 mg/kg, iv measured after 24 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 12 | ALA4304797 | organism-based format | Scientific Literature | |
3. | ALA4307494 | ADME | Clearance in Sprague-Dawley rat at 1 mg/kg, iv measured after 24 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 12 | ALA4304797 | organism-based format | Scientific Literature | |
4. | ALA4307495 | ADME | Volume of distribution at steady state in Sprague-Dawley rat at 1 mg/kg, iv measured after 24 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 10 | ALA4304797 | organism-based format | Scientific Literature | |
5. | ALA4307496 | ADME | Oral bioavailability in Sprague-Dawley rat at 2 mg/kg measured after 24 hrs by HPLC-MS/MS analysis | Rattus norvegicus | 10 | ALA4304797 | organism-based format | Scientific Literature | |
6. | ALA4307499 | Physicochemical | Lipophilicity, chromatographic hydrophobicity index of compound at pH 7.4 | 28 | ALA4304797 | small-molecule physicochemical format | Scientific Literature |