# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4360761 | Binding | Inhibition of human IDO1 expressed in Escherichia coli Rosetta measured after 1 hr by microplate reader analysis | Homo sapiens | 26 | ALA4359827 | assay format | Scientific Literature | |
2. | ALA4360762 | Binding | Inhibition of human TDO expressed in Escherichia coli Rosetta measured after 1 hr microplate reader analysis | Homo sapiens | 25 | ALA4359827 | assay format | Scientific Literature | |
3. | ALA4360763 | Binding | Inhibition of IDO in human HeLa cells using tryptophan as substrate measured after 48 hrs in presence of INF gamma microplate reader analysis | Homo sapiens | 25 | ALA4359827 | cell-based format | Scientific Literature | |
4. | ALA4360764 | ADME | Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate measured after 10 mins in presence of NADPH by UHPLC-MS/MS analysis | Homo sapiens | 5 | ALA4359827 | microsome format | Scientific Literature | |
5. | ALA4360765 | ADME | Inhibition of CYP2C9 in human liver microsomes using tolbutamide as substrate measured after 10 mins in presence of NADPH by UHPLC-MS/MS analysis | Homo sapiens | 5 | ALA4359827 | microsome format | Scientific Literature | |
6. | ALA4360766 | ADME | Inhibition of CYP2C19 in human liver microsomes using s-mephenytoin as substrate measured after 10 mins in presence of NADPH by UHPLC-MS/MS analysis | Homo sapiens | 5 | ALA4359827 | microsome format | Scientific Literature | |
7. | ALA4360767 | ADME | Inhibition of CYP2D6 in human liver microsomes using dextromethorphan as substrate measured after 10 mins in presence of NADPH by UHPLC-MS/MS analysis | Homo sapiens | 5 | ALA4359827 | microsome format | Scientific Literature | |
8. | ALA4360768 | ADME | Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 10 mins in presence of NADPH by UHPLC-MS/MS analysis | Homo sapiens | 5 | ALA4359827 | microsome format | Scientific Literature | |
9. | ALA4360769 | ADME | Inhibition of CYP3A4 in human liver microsomes using testosterone as substrate measured after 10 mins in presence of NADPH by UHPLC-MS/MS analysis | Homo sapiens | 5 | ALA4359827 | microsome format | Scientific Literature | |
10. | ALA4360771 | Binding | Inhibition of human ERG expressed in CHOK1 cells by patch clamp assay | Homo sapiens | 1 | ALA4359827 | cell-based format | Scientific Literature | |
11. | ALA4360772 | ADME | Protein binding in human plasma measured after 4 hrs by rapid equilibrium dialysis | Homo sapiens | 1 | ALA4359827 | cell-free format | Scientific Literature | |
12. | ALA4360773 | ADME | Protein binding in dog plasma measured after 2 to 6 hrs by rapid equilibrium dialysis | Canis lupus familiaris | 1 | ALA4359827 | cell-free format | Scientific Literature | |
13. | ALA4360774 | ADME | Protein binding in mouse plasma measured after 2 to 6 hrs by rapid equilibrium dialysis | Mus musculus | 1 | ALA4359827 | cell-free format | Scientific Literature | |
14. | ALA4360775 | ADME | Half-life in rat liver microsomes | Rattus norvegicus | 1 | ALA4359827 | microsome format | Scientific Literature | |
15. | ALA4360776 | ADME | Half-life in human liver microsomes | Homo sapiens | 1 | ALA4359827 | microsome format | Scientific Literature | |
16. | ALA4360777 | ADME | Cmax in C57BL/6 mouse at 10 mg/kg via oral gavage measured upto 24 hrs | Mus musculus | 1 | ALA4359827 | organism-based format | Scientific Literature | |
17. | ALA4360778 | ADME | AUC in C57BL/6 mouse at 10 mg/kg via oral gavage measured upto 24 hrs | Mus musculus | 1 | ALA4359827 | organism-based format | Scientific Literature | |
18. | ALA4360779 | ADME | Half-life in C57BL/6 mouse at 10 mg/kg via oral gavage measured upto 24 hrs | Mus musculus | 1 | ALA4359827 | organism-based format | Scientific Literature | |
19. | ALA4360780 | ADME | Oral bioavailability in C57BL/6 mouse at 10 mg/kg measured upto 24 hrs | Mus musculus | 1 | ALA4359827 | organism-based format | Scientific Literature | |
20. | ALA4360781 | ADME | Cmax in Sprague-Dawley rat at 10 mg/kg via oral gavage measured upto 24 hrs | Rattus norvegicus | 1 | ALA4359827 | organism-based format | Scientific Literature |