# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4373219 | Binding | Inhibition of human Nav1.7 expressed in HEK293 cells after 600 secs at -60 mV holding potential by ion works barracuda population patch clamp method | Homo sapiens | 64 | ALA4371076 | cell-based format | Scientific Literature | |
2. | ALA4373220 | ADME | Inhibition of human Nav1.5 expressed in HEK293 cells after 600 secs at -50 mV holding potential by ion works barracuda population patch clamp method | Homo sapiens | 55 | ALA4371076 | cell-based format | Scientific Literature | |
3. | ALA4373221 | Binding | Inhibition of recombinant human Nav1.7 expressed in HEK293 cells at -70 mV holding potential by patch clamp electrophysiology method | Homo sapiens | 15 | ALA4371076 | cell-based format | Scientific Literature | |
4. | ALA4373222 | ADME | Metabolic stability in human liver microsomes assessed as parent compound remaining at 0.5 uM after 10 mins | Homo sapiens | 15 | ALA4371076 | microsome format | Scientific Literature | |
5. | ALA4373223 | ADME | Metabolic stability in rat liver microsomes assessed as parent compound remaining at 0.5 uM after 10 mins | Rattus norvegicus | 15 | ALA4371076 | microsome format | Scientific Literature | |
6. | ALA4373224 | ADME | Metabolic stability in mouse liver microsomes assessed as parent compound remaining at 0.5 uM after 10 mins | Mus musculus | 14 | ALA4371076 | microsome format | Scientific Literature | |
7. | ALA4373225 | ADME | Fraction unbound in human plasma | Homo sapiens | 15 | ALA4371076 | cell-free format | Scientific Literature | |
8. | ALA4373226 | ADME | Fraction unbound in mouse plasma | Mus musculus | 15 | ALA4371076 | cell-free format | Scientific Literature | |
9. | ALA4373227 | ADME | Permeability of the compound at pH 5.5 by PAMPA | 14 | ALA4371076 | assay format | Scientific Literature | ||
10. | ALA4373228 | ADME | Permeability of the compound at pH 7.4 by PAMPA | 15 | ALA4371076 | assay format | Scientific Literature | ||
11. | ALA4373229 | ADME | Permeability from apical to basolateral side in human Caco2 cells | Homo sapiens | 15 | ALA4371076 | cell-based format | Scientific Literature | |
12. | ALA4373230 | ADME | Permeability from basolateral to apical side in human Caco2 cells | Homo sapiens | 15 | ALA4371076 | cell-based format | Scientific Literature | |
13. | ALA4373231 | ADME | Efflux ratio of permeability in human Caco2 cells | Homo sapiens | 15 | ALA4371076 | cell-based format | Scientific Literature | |
14. | ALA4373232 | ADME | Inhibition of CYP2B6 in human liver microsomes | Homo sapiens | 15 | ALA4371076 | microsome format | Scientific Literature | |
15. | ALA4373233 | ADME | Inhibition of CYP2C8 in human liver microsomes | Homo sapiens | 15 | ALA4371076 | microsome format | Scientific Literature | |
16. | ALA4373234 | ADME | Inhibition of CYP2C9 in human liver microsomes | Homo sapiens | 15 | ALA4371076 | microsome format | Scientific Literature | |
17. | ALA4373235 | ADME | Inhibition of CYP2C19 in human liver microsomes | Homo sapiens | 15 | ALA4371076 | microsome format | Scientific Literature | |
18. | ALA4373236 | ADME | Inhibition of CYP2D6 in human liver microsomes | Homo sapiens | 15 | ALA4371076 | microsome format | Scientific Literature | |
19. | ALA4373237 | ADME | Inhibition of CYP3A4 in human liver microsomes | Homo sapiens | 15 | ALA4371076 | microsome format | Scientific Literature | |
20. | ALA4373238 | ADME | Time-dependant inhibition of CYP2B6 in human liver microsomes | Homo sapiens | 15 | ALA4371076 | microsome format | Scientific Literature |