# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4479425 | ADME | Intrinsic clearance in rat liver microsomes assessed per mg of protein at 1 uM preincubated for 5 mins followed by NADPH addition measured after 5 to 30 mins by LC-MS/MS analysis | Rattus norvegicus | 14 | ALA4477239 | microsome format | Scientific Literature | |
2. | ALA4479426 | Binding | Inhibition of c-Met kinase (unknown origin) assessed as decrease in phosphorylation of TK substrate-biotin peptide preincubated for 5 to 10 mins followed by ATP addition measured after 30 mins by HTRF assay | Homo sapiens | 84 | ALA4477239 | single protein format | Scientific Literature | |
3. | ALA4479427 | Functional | Cytotoxicity against human NCI-H1993 cells assessed as growth inhibition after 72 hrs by CCK-8 assay | Homo sapiens | 84 | ALA4477239 | cell-based format | Scientific Literature | |
4. | ALA4479428 | ADME | Intrinsic clearance in human liver microsomes assessed per mg of protein at 1 uM preincubated for 5 mins followed by NADPH addition measured after 5 to 30 mins by LC-MS/MS analysis | Homo sapiens | 14 | ALA4477239 | microsome format | Scientific Literature | |
5. | ALA4479430 | ADME | Inhibition of CYP2D6 in human liver microsomes at 10 uM using quinidine as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins by LC-MS/MS analysis | Homo sapiens | 5 | ALA4477239 | microsome format | Scientific Literature | |
6. | ALA4479431 | ADME | Inhibition of CYP2C9 in human liver microsomes at 10 uM using sulfaphenazole as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins by LC-MS/MS analysis | Homo sapiens | 14 | ALA4477239 | microsome format | Scientific Literature | |
7. | ALA4479433 | ADME | Inhibition of CYP2C19 in human liver microsomes at 10 uM using tranylcypromine as substrate preincubated for 5 mins followed by NADPH addition measured after 20 mins by LC-MS/MS analysis | Homo sapiens | 7 | ALA4477239 | microsome format | Scientific Literature | |
8. | ALA4479434 | ADME | Time-dependent inhibition of CYP3A4 in human liver microsomes at 10 uM using troleandomycin as substrate preincubated with compound followed by NADPH addition by LC-MS/MS analysis | Homo sapiens | 14 | ALA4477239 | microsome format | Scientific Literature | |
9. | ALA4479435 | ADME | Time-dependent inhibition of CYP2D6 in human liver microsomes at 10 uM using paroxetine as substrate preincubated with compound followed by NADPH addition by LC-MS/MS analysis | Homo sapiens | 12 | ALA4477239 | microsome format | Scientific Literature | |
10. | ALA4479437 | ADME | Time-dependent inhibition of CYP1A2 in human liver microsomes at 10 uM using furafylline as substrate preincubated with compound followed by NADPH addition by LC-MS/MS analysis | Homo sapiens | 12 | ALA4477239 | microsome format | Scientific Literature |