# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4340781 | Binding | Inhibition of human serum BuChE at 10 uM using butyrylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition and measured at 1 min time interval by Ellman's method relative to control | Homo sapiens | 22 | ALA4340508 | single protein format | Scientific Literature | |
2. | ALA4340782 | Functional | Antineuroinflammatory activity in mouse BV2 cells assessed as inhibition of LPS-induced nitric oxide production pretreated for 30 mins followed by LPS-stimulation for 24 hrs by Griess assay | Mus musculus | 23 | ALA4340508 | cell-based format | Scientific Literature | |
3. | ALA4340783 | Binding | Inhibition of recombinant human BACE1 at 20 uM preincubated with enzyme for 20 mins followed by addition of Rh-EVNLDAEFK-Quencher as substrate measured after 60 mins by FRET assay relative to control | Homo sapiens | 23 | ALA4340508 | single protein format | Scientific Literature | |
4. | ALA4340785 | ADME | Permeability of the compound in PBS/EtOH at 100 ug/ml after 10 hrs by PAMPA-BBB assay | 24 | ALA4340508 | assay format | Scientific Literature | ||
5. | ALA4340796 | Binding | Inhibition of human erythrocyte AChE at 10 uM using acetylthiocholine chloride as substrate preincubated for 15 mins followed by substrate addition and measured at 1 min time interval by Ellman's method relative to control | Homo sapiens | 22 | ALA4340508 | single protein format | Scientific Literature |