# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4380517 | B | Inhibition of recombinant full length human N-terminal His-tagged TBK1 using biotin-labelled Ahx-GDEDFSSFAEPG peptide as substrate preincubated with enzyme for 15 mins followed by substrate addition and further incubated for 30 mins in presence of 10 uM of ATP by TR-FRET assay | Homo sapiens | 37 | ALA4376867 | single protein format | Scientific Literature | |
2. | ALA4380518 | B | Inhibition of recombinant full length human N-terminal His-tagged TBK1 using biotin-labelled Ahx-GDEDFSSFAEPG peptide as substrate preincubated with enzyme for 15 mins followed by substrate addition and further incubated for 30 mins in presence of 1 mM of ATP by TR-FRET assay | Homo sapiens | 37 | ALA4376867 | single protein format | Scientific Literature | |
3. | ALA4380519 | B | Inhibition of recombinant full length human C-terminal GST-tagged IKKepsilon expressed in baculovirus expression system using biotin-labelled Ahx-GDEDFSSFAEPG peptide as substrate preincubated with enzyme for 15 mins followed by substrate addition and further incubated for 30 mins in presence of 10 uM of ATP by TR-FRET assay | Homo sapiens | 37 | ALA4376867 | assay format | Scientific Literature | |
4. | ALA4380520 | B | Inhibition of IKKepsilon/TBK1 in human MDB-MB-231 cells transduced with lentiviral vector expressing human IRF3 assessed as decrease in poly(I:C)-stimulated IRF3 phosphorylation at S385/386 residues preincubated for 1 hr followed by poly(I:C) addition and measured after 1 hr | Homo sapiens | 37 | ALA4376867 | cell-based format | Scientific Literature | |
5. | ALA4380521 | F | Antiproliferative activity against human SK-MEL-2 cells harboring NRAS/TP53 mutation assessed as reduction in cell viability after 96 hrs by CellTiter-Glo luminescence assay | Homo sapiens | 37 | ALA4376867 | cell-based format | Scientific Literature | |
6. | ALA4380522 | F | Antiproliferative activity against human ACHN cells harboring CDKN2A mutation assessed as reduction in cell viability after 96 hrs by CellTiter-Glo luminescence assay | Homo sapiens | 37 | ALA4376867 | cell-based format | Scientific Literature |