# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4306808 | ADME | Efflux ratio of permeability across basolateral to apical over apical to basolateral in Doxycycline induced dog MDCK cells transfected with mouse BCRP | Canis lupus familiaris | 1 | ALA4304767 | cell-based format | Scientific Literature | |
2. | ALA4306809 | Functional | Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isoproterenol-induced cAMP accumulation incubated for 7 mins in presence of isoproterenol by Glosensor cAMP reagent/plate reader based luminescence assay | Homo sapiens | 27 | ALA4304767 | cell-based format | Scientific Literature | |
3. | ALA4306811 | ADME | Agonist activity at human Muscarinic acetylcholine receptor M2 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isoproterenol-induced cAMP accumulation incubated for 7 mins in presence of isoproterenol by Glosensor cAMP reagent/plate reader based luminescence assay | Homo sapiens | 8 | ALA4304767 | cell-based format | Scientific Literature | |
4. | ALA4306812 | ADME | Efflux ratio of permeability across basolateral to apical over apical to basolateral in dog MDCK cells transfected with MDR1 gene | Canis lupus familiaris | 1 | ALA4304767 | cell-based format | Scientific Literature | |
5. | ALA4306813 | Functional | Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isoproterenol-induced cAMP accumulation at 10 uM to 0.3 nM incubated for 2 hrs in presence of isoproterenol and measured after 7 mins by Glosensor cAMP reagent/plate reader based luminescence assay relative to acetylcholine | Homo sapiens | 17 | ALA4304767 | cell-based format | Scientific Literature | |
6. | ALA4306815 | ADME | Agonist activity at human Muscarinic acetylcholine receptor M2 expressed in HEK cells co-expressing Glosensor construct assessed as decrease in isoproterenol-induced cAMP accumulation at 10 uM to 0.3 nM incubated for 7 mins in presence of isoproterenol by Glosensor cAMP reagent/plate reader based luminescence assay relative to acetylcholine | Homo sapiens | 6 | ALA4304767 | cell-based format | Scientific Literature |