# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4352819 | Functional | Antiviral activity against Enterovirus A71 infected in human RD cells assessed as reduction in virus-induced cell death incubated for 4 days by CellTiter-Glo luminescence assay | Enterovirus A71 | 31 | ALA4350972 | organism-based format | Scientific Literature | |
2. | ALA4352820 | ADME | Cytotoxicity against human RD cells incubated for 4 days by CellTiter-Glo luminescence assay | Homo sapiens | 31 | ALA4350972 | cell-based format | Scientific Literature | |
3. | ALA4352821 | Binding | Inhibition of human recombinant GST-tagged mTOR catalytic domain (1360 to 2549 residues) expressed in baculovirus expression system using GFP-4E-BP1 peptide as substrate incubated for 1 hr by LanthaScreen assay | Homo sapiens | 3 | ALA4350972 | assay format | Scientific Literature | |
4. | ALA4352822 | Binding | Inhibition of mTORC1 in human RD cells assessed as reduction in P70S6K1 phosphorylation at Thr 389 site at 20 uM incubated for 2 hrs in presence of insulin by Western blot analysis | Homo sapiens | 22 | ALA4350972 | cell-based format | Scientific Literature | |
5. | ALA4352823 | Binding | Inhibition of mTORC2 in human RD cells assessed as reduction in Akt phosphorylation at Ser473 site at 20 uM incubated for 2 hrs in presence of insulin by Western blot analysis | Homo sapiens | 19 | ALA4350972 | cell-based format | Scientific Literature | |
6. | ALA4352824 | Physicochemical | Aqueous solubility of the compound | 6 | ALA4350972 | small-molecule physicochemical format | Scientific Literature |