| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4401823 | B | Inhibition of recombinant human GST-tagged CLK2 expressed in baculovirus expression system at 1 uM by kinomescan assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 2. | ALA4401824 | B | Inhibition of recombinant human GST-tagged CLK1 expressed in Escherichia coli at 1 uM by kinomescan assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 3. | ALA4401827 | B | Inhibition of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) autophosphorylation at S724 after 25 mins in presence of ATP by dissociation-enhanced lanthanide fluorescence immunoassay | Homo sapiens | 25 | single protein format | Scientific Literature | ||
| 4. | ALA4401828 | B | Displacement for LanthaScreen tracer from dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) ATP binding site KEN domain after 60 mins by FRET assay | Homo sapiens | 24 | single protein format | Scientific Literature | ||
| 5. | ALA4401829 | B | Inhibition of dephosphorylated IRE1alpha (G547 to L977 residues) (unknown origin) -dependent cleavage of FAM-labeled stem-loop RNA containing the XBP1 cleavage site preincubated for 30 mins followed by RNA XBP1 substrate addition and measured after 15 mins by FRET assay | Homo sapiens | 24 | single protein format | Scientific Literature | ||
| 6. | ALA4401831 | B | Inhibition of tunicamycin-induced IRE1alpha (unknown origin) expressed in HEK293 cells assessed as reduction in IRE1alpha-dependent splicing of XBP1u-luciferase mRNA by luciferase reporter gene assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 7. | ALA4401832 | A | Cytotoxicity against HEK293 cells co-expressing XBP1u-mRNA by luciferase reporter gene assay | Homo sapiens | 6 | cell-based format | Scientific Literature | ||
| 8. | ALA4401833 | P | Aqueous kinetic solubility of the compound | 6 | small-molecule physicochemical format | Scientific Literature | |||
| 9. | ALA4401834 | P | Distribution coefficient, log D of the compound at pH 7.4 | 4 | small-molecule physicochemical format | Scientific Literature | |||
| 10. | ALA4401835 | B | Inhibition of recombinant full length human GST-tagged CLK4 expressed in baculovirus expression system at 1 uM by kinomescan assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 11. | ALA4401836 | B | Inhibition of recombinant full length human GST-tagged DYRK1A expressed in baculovirus expression system at 1 uM by kinomescan assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 12. | ALA4401837 | B | Inhibition of recombinant full length human GST-tagged DYRK1B expressed in baculovirus expression system at 1 uM by kinomescan assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 13. | ALA4401842 | B | Inhibition of recombinant human His-tagged HIPK4 expressed in baculovirus expression system at 1 uM by kinomescan assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 14. | ALA4401845 | B | Inhibition of recombinant human His-tagged FLT3 expressed in baculovirus expression system at 1 uM by kinomescan assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 15. | ALA4401846 | B | Inhibition of recombinant human His-tagged FLT3 ITD mutant expressed in baculovirus expression system at 1 uM by kinomescan assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 16. | ALA4401850 | B | Inhibition of recombinant human His-tagged FLT3 N8411 mutant expressed in baculovirus expression system at 1 uM by kinomescan assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 17. | ALA4401851 | B | Inhibition of recombinant human His-tagged KIT expressed in baculovirus expression system at 1 uM by kinomescan assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 18. | ALA4401852 | B | Inhibition of recombinant human His-tagged KIT L576P mutant expressed in baculovirus expression system at 1 uM by kinomescan assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 19. | ALA4401853 | B | Inhibition of recombinant human His-tagged KIT V559D mutant expressed in baculovirus expression system at 1 uM by kinomescan assay relative to control | Homo sapiens | 2 | assay format | Scientific Literature | ||
| 20. | ALA4401858 | B | Inhibition of recombinant human His-tagged PDGFRB expressed in baculovirus expression system at 1 uM by kinomescan assay relative to control | Homo sapiens | 1 | assay format | Scientific Literature |
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