| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4424848 | B | Inhibition of human CSF1R tyrosine kinase domain (538 to 972 residues) using Poly(Glu, Tyr)-biotinylated peptide as substrate preincubated for 5 mins followed by substrate addition and measured after 10 mins by HTRF assay | Homo sapiens | 21 | ALA4422686 | single protein format | Scientific Literature | |
| 2. | ALA4424849 | B | Inhibition of CSF1R in CSF1-induced DBA/1J mouse BMMC assessed as reduction in LPS-induced IL6 production preincubated for overnight followed by LPS-stimulation and measured after 6 hrs by ELISA | Mus musculus | 21 | ALA4422686 | single protein format | Scientific Literature | |
| 3. | ALA4424850 | P | Aqueous solubility of the compound in pH 7.2 phosphate buffered saline | 21 | ALA4422686 | small-molecule physicochemical format | Scientific Literature | ||
| 4. | ALA4424851 | A | Stability in human liver S9 fraction assessed as parent compound remaining at 5 uM preincubated for 5 mins followed by NADPH addition and measured after 60 mins by LC-MS/MS analysis | Homo sapiens | 21 | ALA4422686 | subcellular format | Scientific Literature | |
| 5. | ALA4424852 | A | Stability in Sprague-Dawley rat liver S9 fraction assessed as parent compound remaining at 5 uM preincubated for 5 mins followed by NADPH addition and measured after 60 mins by LC-MS/MS analysis | Rattus norvegicus | 21 | ALA4422686 | subcellular format | Scientific Literature | |
| 6. | ALA4424853 | A | Stability in CD-1 mouse liver S9 fraction assessed as parent compound remaining at 5 uM preincubated for 5 mins followed by NADPH addition and measured after 60 mins by LC-MS/MS analysis | Mus musculus | 21 | ALA4422686 | subcellular format | Scientific Literature | |
| 7. | ALA4424854 | F | Invivo inhibition of CSF1R in CSF1-induced DBA/1J mouse assessed as reduction in LPS-induced IL6 production at 10 mg/kg, po treated for 1 hr prior to CSF1-stimulation followed by LPS-addition and measured after 2 hrs by ELISA relative to control | Mus musculus | 21 | ALA4422686 | organism-based format | Scientific Literature | |
| 8. | ALA4424855 | F | Invivo inhibition of CSF1R in CSF1-induced DBA/1J mouse assessed as reduction in LPS-induced IL6 production at 10 mg/kg, po treated for 6 hrs prior to CSF1-stimulation followed by LPS-addition and measured after 2 hrs by ELISA relative to control | Mus musculus | 21 | ALA4422686 | organism-based format | Scientific Literature | |
| 9. | ALA4424857 | A | Cmax in Sprague-Dawley rat at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4422686 | organism-based format | Scientific Literature | |
| 10. | ALA4424858 | A | AUC in Sprague-Dawley rat at 3 mg/kg, po by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4422686 | organism-based format | Scientific Literature | |
| 11. | ALA4424859 | A | Oral bioavailability in Sprague-Dawley rat at 3 mg/kg by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4422686 | organism-based format | Scientific Literature | |
| 12. | ALA4424860 | A | Clearance in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4422686 | organism-based format | Scientific Literature | |
| 13. | ALA4424861 | A | Half life in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4422686 | organism-based format | Scientific Literature | |
| 14. | ALA4424862 | A | Volume of distribution in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4422686 | organism-based format | Scientific Literature | |
| 15. | ALA4424863 | A | Mean residence time in Sprague-Dawley rat at 1 mg/kg, iv by LC-MS/MS analysis | Rattus norvegicus | 3 | ALA4422686 | organism-based format | Scientific Literature | |
| 16. | ALA4424864 | A | Clearance in cynomolgus monkey at 1 mg/kg, iv by LC-MS/MS analysis | Macaca fascicularis | 3 | ALA4422686 | organism-based format | Scientific Literature | |
| 17. | ALA4424865 | A | Half life in cynomolgus monkey at 1 mg/kg, iv by LC-MS/MS analysis | Macaca fascicularis | 3 | ALA4422686 | organism-based format | Scientific Literature | |
| 18. | ALA4424866 | A | Volume of distribution in cynomolgus monkey at 1 mg/kg, iv by LC-MS/MS analysis | Macaca fascicularis | 3 | ALA4422686 | organism-based format | Scientific Literature | |
| 19. | ALA4424867 | A | Mean residence time in cynomolgus monkey at 1 mg/kg, iv by LC-MS/MS analysis | Macaca fascicularis | 3 | ALA4422686 | organism-based format | Scientific Literature |
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