# | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
---|---|---|---|---|---|---|---|---|---|
1. | ALA4420222 | F | Protection against light-induced retinal degeneration in Sprague-Dawley rat assessed as improvement in retinal outer nuclear layer thickness in superior retina at 50 mg/kg, ip dosed 0.5 hrs before 6 hrs light exposure relative to control | Rattus norvegicus | 4 | organism-based format | Patent Bioactivity Data | ||
2. | ALA4420247 | B | Inhibition of RPE65 in bovine RPE microsomes assessed as reduction in isomero-hydrolase activity using all-trans-[3H]-retinol by normal phase HPLC with flow scintillation analysis | Bos taurus | 11 | assay format | Patent Bioactivity Data | ||
3. | ALA4420248 | F | Inhibition of rhodopsin regeneration in overnight dark-adaptated Sprague-Dawley rat assessed as effect on rhodopsin recovery by measuring rhodopsin content at 50 mg/kg, ip followed by exposure to room light for 2 hrs and measured 2.5 hrs after photo-bleach by spectrophotometry | Rattus norvegicus | 4 | organism-based format | Patent Bioactivity Data | ||
4. | ALA4420249 | F | Inhibition of rhodopsin regeneration in overnight dark-adaptated Sprague-Dawley rat assessed as effect on rhodopsin recovery by measuring reduction in rhodopsin content at 50 mg/kg, ip followed by exposure to room light for 2 hrs and measured 2.5 hrs after photo-bleach by spectrophotometry relative to control | Rattus norvegicus | 4 | organism-based format | Patent Bioactivity Data | ||
5. | ALA4420250 | F | Protection against light-induced retinal degeneration in overnight dark-adaptated Sprague-Dawley rat assessed as protection of retinal rod function by measuring effect on A-waves at 50 mg/kg, ip dosed 30 mins prior to exposure to 4 log cd.s/m2 test flash by electroretinography relative to control | Rattus norvegicus | 4 | organism-based format | Patent Bioactivity Data | ||
6. | ALA4420251 | F | Protection against light-induced retinal degeneration in overnight dark-adaptated Sprague-Dawley rat assessed as protection of retinal rod function by measuring effect on B-waves at 50 mg/kg, ip dosed 30 mins prior to exposure to 4 log cd.s/m2 test flash by electroretinography relative to control | Rattus norvegicus | 4 | organism-based format | Patent Bioactivity Data | ||
7. | ALA4420252 | F | Protection against light-induced retinal degeneration in overnight dark-adaptated Sprague-Dawley rat assessed as protection of retinal rod and cone function by measuring effect on A-waves at 50 mg/kg, ip dosed 30 mins prior to exposure to 400 log cd.s/m2 test flash by electroretinography relative to control | Rattus norvegicus | 4 | organism-based format | Patent Bioactivity Data | ||
8. | ALA4420253 | F | Protection against light-induced retinal degeneration in overnight dark-adaptated Sprague-Dawley rat assessed as protection of retinal rod and cone function by measuring effect on B-waves at 50 mg/kg, ip dosed 30 mins prior to exposure to 400 log cd.s/m2 test flash by electroretinography relative to control | Rattus norvegicus | 4 | organism-based format | Patent Bioactivity Data | ||
9. | ALA4420254 | F | Protection against light-induced retinal degeneration in Sprague-Dawley rat assessed as photoreceptor levels in central and superior retina at 50 mg/kg, ip dosed 0.5 hrs before 6 hrs light exposure relative to control | Rattus norvegicus | 4 | organism-based format | Patent Bioactivity Data | ||
10. | ALA4420255 | F | Protection against light-induced retinal degeneration in Sprague-Dawley rat assessed as improvement in retinal outer nuclear layer thickness in inferior retina at 50 mg/kg, ip dosed 0.5 hrs before 6 hrs light exposure relative to control | Rattus norvegicus | 4 | organism-based format | Patent Bioactivity Data | ||
11. | ALA4420263 | F | Inhibition of rhodopsin regeneration in completely light-adapted mouse BALB/c mouse assessed as rhodopsin recovery level by measuring effect on rhodopsin content at 5% dosed to eyes via eye drop before dark adaptation for 1 hr by spectrophotometry (Rvb = 78.83%) | Mus musculus | 10 | organism-based format | Patent Bioactivity Data |