| # | Aladdin ID | Assay Type | Description | Organism | Compounds | Reference | BAO Format | Source | |
|---|---|---|---|---|---|---|---|---|---|
| 1. | ALA4356464 | B | Inhibition of P-gp overexpressed in human DU145-TxR cells assessed as increase in cellular accumulation of calcein AM at 2 uM pretreated followed by calcein AM addition by fluorescence imaging analysis | Homo sapiens | 11 | ALA4354820 | cell-based format | Scientific Literature | |
| 2. | ALA4356465 | B | Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 3 uM after 48 hrs by MTT assay (Rvb = 2120 nM) | Homo sapiens | 11 | ALA4354820 | cell-based format | Scientific Literature | |
| 3. | ALA4356466 | B | Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxicity by measuring fold reduction paclitaxel IC50 at 7 uM after 48 hrs by MTT assay relative to paclitaxel alone | Homo sapiens | 11 | ALA4354820 | cell-based format | Scientific Literature | |
| 4. | ALA4356467 | B | Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxicity by measuring fold reduction paclitaxel IC50 at 5 uM after 48 hrs by MTT assay relative to paclitaxel alone | Homo sapiens | 11 | ALA4354820 | cell-based format | Scientific Literature | |
| 5. | ALA4356468 | B | Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxicity by measuring fold reduction paclitaxel IC50 at 3 uM after 48 hrs by MTT assay relative to paclitaxel alone | Homo sapiens | 11 | ALA4354820 | cell-based format | Scientific Literature | |
| 6. | ALA4356469 | B | Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxicity by measuring fold reduction paclitaxel IC50 at 3 uM after 48 hrs by MTT assay relative to parent compound | Homo sapiens | 11 | ALA4354820 | cell-based format | Scientific Literature | |
| 7. | ALA4356470 | B | Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxicity by measuring fold reduction paclitaxel IC50 at 10 uM after 48 hrs by MTT assay relative to paclitaxel alone | Homo sapiens | 11 | ALA4354820 | cell-based format | Scientific Literature | |
| 8. | ALA4356471 | B | Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxicity by measuring fold reduction paclitaxel IC50 at 5 uM after 48 hrs by MTT assay relative to parent compound | Homo sapiens | 11 | ALA4354820 | cell-based format | Scientific Literature | |
| 9. | ALA4356472 | B | Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxicity by measuring fold reduction paclitaxel IC50 at 7 uM after 48 hrs by MTT assay relative to parent compound | Homo sapiens | 11 | ALA4354820 | cell-based format | Scientific Literature | |
| 10. | ALA4356473 | B | Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxicity by measuring fold reduction paclitaxel IC50 at 10 uM after 48 hrs by MTT assay relative to parent compound | Homo sapiens | 11 | ALA4354820 | cell-based format | Scientific Literature | |
| 11. | ALA4356474 | B | Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 5 uM after 48 hrs by MTT assay (Rvb = 2120 nM) | Homo sapiens | 11 | ALA4354820 | cell-based format | Scientific Literature | |
| 12. | ALA4356475 | B | Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 7 uM after 48 hrs by MTT assay (Rvb = 2120 nM) | Homo sapiens | 11 | ALA4354820 | cell-based format | Scientific Literature | |
| 13. | ALA4356476 | B | Reversal of P-gp mediated multidrug resistance in human DU145-TxR cells overexpressing P-gp assessed as potentiation of paclitaxel-induced cytotoxicity by measuring paclitaxel IC50 at 10 uM after 48 hrs by MTT assay (Rvb = 2120 nM) | Homo sapiens | 11 | ALA4354820 | cell-based format | Scientific Literature | |
| 14. | ALA4356477 | B | Inhibition of P-gp overexpressed in human DU145-TxR cells assessed as increase in cellular accumulation of calcein AM at 2 uM preincubated for 6 hrs followed by calcein AM addition by fluorescence imaging analysis | Homo sapiens | 11 | ALA4354820 | cell-based format | Scientific Literature | |
| 15. | ALA4356480 | B | Effect on verampil-mediated ATPase hydrolysis of recombinant mouse MDR3 expressed in Pichia pastoris measured after 30 mins in presence of NADH by coupled enzyme assay (Rvb = 100 +/- 8 %) | Mus musculus | 3 | ALA4354820 | assay format | Scientific Literature | |
| 16. | ALA4356482 | B | Stimulation of basal ATPase hydrolysis in recombinant mouse MDR3 expressed in Pichia pastoris measured after 30 mins in presence of NADH by coupled enzyme assay (Rvb = 100 +/- 7 %) | Mus musculus | 4 | ALA4354820 | assay format | Scientific Literature | |
| 17. | ALA4356484 | B | Inhibition of P-gp overexpressed in human DU145-TxR cells assessed as increase in intracellular compound accumulation after 2.5 hrs in presence of tariquidar by LC-MS/MS analysis | Homo sapiens | 5 | ALA4354820 | cell-based format | Scientific Literature | |
| 18. | ALA4356486 | B | Ratio of inhibition of P-gp overexpressed in human DU145-TxR cells assessed as increase in intracellular compound accumulation after 2.5 hrs in presence of tariquidar by LC-MS/MS analysis to Inhibition of P-gp overexpressed in human DU145-TxR cells assessed as decrease in intracellular compound accumulation after 2.5 hrs in absence of tariquidar by LC-MS/MS analysis | Homo sapiens | 11 | ALA4354820 | cell-based format | Scientific Literature | |
| 19. | ALA4356487 | B | Inhibition of 2',3'-(2,2,5,5,-tetramethyl-3-pyrroline-l-oxyl-3-carboxylic acid ester)ATP interaction with human P-gp expressed in Escherichia coli BL21 (DE3) assessed as reduction in ATP binding from 2 to 1 of nucleotide to mol of protein by ESR analysis (Rvb = 1.8 +/- 0.1 No_unit) | Homo sapiens | 11 | ALA4354820 | assay format | Scientific Literature | |
| 20. | ALA4356488 | B | Inhibition of spin-labelled adenine nucleotide interaction with human P-gp expressed in Escherichia coli BL21 (DE3) assessed as apparent dissociation constant by ESR analysis (Rvb = 36.5 +/- 3.6 uM) | Homo sapiens | 11 | ALA4354820 | assay format | Scientific Literature |
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